Lanosterol 14 alpha-demethylase: Information from Answers.com

cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
Symbol	CYP51A1
Alt. Symbols	CYP51, P45014DM
Entrez	1595
HUGO	2649
OMIM	601637
RefSeq	NM_000786
UniProt	Q16850
Other data
EC number	1.14.13.70
Locus	Chr. 7 q21.2-21.3

CYP51A1 (or lanosterol 14 alpha-demethylase, P45014DM) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) which converts lanosterol to cholesterol.

It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.^[1]

Lanosterol

Ergosterol

Cholesterol

References

^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). "Antifungal drug resistance in pathogenic fungi". Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500.

External links

MeSH cytochrome+P-450+CYP51

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Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase · Geranyl pyrophosphate

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

To Bile acids

Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase

aldosterone: 18-hydroxylase

cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2)

both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase

To estrogens	Aromatase

Other/ungrouped

Steroid sulfatase · Steroidogenic acute regulatory protein

see also intermediates, disorders

v • d • e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11: 2-oxoglutarate	Prolyl hydroxylase - Lysyl hydroxylase

1.14.13: NADH or NADPH	Flavin-containing monooxygenase (FMO1, FMO2, FMO3, FMO4, FMO5) - Nitric oxide synthase (NOS1, NOS2A, NOS3) - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 - Lanosterol 14 alpha-demethylase

1.14.14: reduced flavin or flavoprotein	19A1 - 2D6 - 2E1

1.14.15: reduced iron-sulfur protein	11B1 - 11B2 - 11A1

1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase

1.14.17: reduced ascorbate	Dopamine beta hydroxylase

1.14.18-19: other	Tyrosinase - Stearoyl-CoA desaturase-1

1.14.99 - miscellaneous	Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1	A1 · A2 · B1

CYP2	A6 · A7 · A13 · B6 · C8 · C9 · C18 · C19 · D6 · E1 · F1 · J2 · R1 · S1 · U1 · W1

CYP3 (CYP3A)	A4 · A5 · A7 · A43

CYP4	A11 · A22 · B1 · F2 · F3 · F8 · F11 · F12 · F22 · V2 · X1 · Z1

CYP5-20	CYP5 (A1) · CYP7 (A1, B1) · CYP8 (A1, B1) · CYP11 (A1, B1, B2) · CYP17 (A1) · CYP19 (A1) · CYP20 (A1)

CYP21-51	CYP21 (A2) · CYP24 (A1) · CYP26 (A1, B1, C1) · CYP27 (A1, B1, C1) · CYP39 (A1) · CYP46 (A1) · CYP51 (A1)

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	Steroid hydroxylases
	Phytanoyl-CoA hydroxylase
	Cholesterol 7 alpha-hydroxylase

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Lanosterol 14 alpha-demethylase

See also

References

External links