The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine and 5-HT3 receptors that are composed of five protein subunits and possess a characteristic loop formed by a disulfide bond between two cysteine (Cys) residues.
The neurotransmitters bind at the interface between subunits in the extracellular domain.
Each subunit contains 4 membrane-spanning alpha helixes (M1, M2, M3, M4), where M2 is the pore lining segment.
The M3-M4 linker is the intracellular domain that binds the cytoskeleton.
References
- Sine S, Engel A (2006). "Recent advances in Cys-loop receptor structure and function.". Nature 440 (7083): 448–55. doi:. PMID 16554804.
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