David Byrne may refer to:
- David Byrne (born 1952), musician and former Talking Heads frontman
- David Byrne (album), his eponymous album
- David Byrne (footballer born 1905), Irish footballer
- David Byrne (footballer born 1961), English football player who played in England
- David Byrne (footballer born 1979), Irish footballer
- David Byrne (politician) (born 1947), Irish and European official
- David Byrne (South African footballer), (born c.1961), South African soccer player who played in North America
See also
- David Burn, Tasmanian pioneer and dramatist
- David Burns (disambiguation)
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