Delgadillo may refer to:

• Angel Delgadillo, the creator of the first Route 66 Association‎‎
• Antonio Pérez Delgadillo (born 1978), Mexican football goalkeeper
• Ceyli Delgadillo, voice actress who is from Arlington, Texas
• Diego Delgadillo (born 1533), judge of the first Audiencia of New Spain
• Fernando Delgadillo (born 1965), Latin American musician and composer
• Jenaro Sánchez Delgadillo (1886–1927), Mexican martyr who died in the Cristero War
• Juan Delgadillo, the first owner of the historic eatery Delgadillo's Snow Cap Drive-In
• Robert A. Delgadillo (Born 1971), also known as RAD, an artist whose work explores and celebrates pop culture
• Rocky Delgadillo (born 1960), the current City Attorney of Los Angeles, California

This page or section lists people with the surname Delgadillo. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.