The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.
Pathology
Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]
References
- ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMID 16211092. PMC: 1242188. http://dx.doi.org/10.1172/JCI23475.
- ^ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. PMID 12705872. http://linkinghub.elsevier.com/retrieve/pii/S0092867403002733.
- ^ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol.. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767. http://dx.doi.org/10.1111/j.1365-2230.2009.03241.x.
External links
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
