Dextrorphan: Information from Answers.com



Dextrorphan
Systematic (IUPAC) name
17-methyl-9a,13a,14a-morphinan-3-ol
Identifiers
CAS number	125-73-5
ATC code	none
PubChem	5360697
Chemical data
Formula	C₁₇H₂₃N O
Mol. mass	257.371 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule I(US)
Routes	?

Dextrorphan (DXO), or more appropriately dextrorphanol, is a psychoactive drug of the morphinan chemical class which acts as a dissociative psychedelic and putative cough suppressant or antitussive. It is the dextro- stereoisomer of morphanol, the levo- halve being levorphanol. Dextrorphanol is also the primary active metabolite of dextromethorphan (DXM).

1 Pharmacology
2 Legality
3 See also
4 References

Pharmacology

Dextrorphan acts primarily as an uncompetitive NMDA receptor antagonist. It also functions as a sigma receptor agonist and serotonin reuptake inhibitor (SRI), among other effects. Regarding its analogue dextromethorphan which is relatively weak at the NMDA receptor, dextrorphan is a much more potent ligand in comparison.^[1]

Legality

Dextrorphan is a Schedule I controlled substance in the United States.^[2]

References

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Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (August 2009)

Cough and cold preparations (R05)

Expectorants

Althea root • Antimony pentasulfide • Creosote • Guaiacolsulfonate • Guaifenesin • Ipecacuanha (Syrup of ipecac) • Levoverbenone • Potassium iodide • Senega • Tyloxapol

Mucolytics

Acetylcysteine • Ambroxol • Bromhexine • Carbocisteine • Domiodol • Dornase alfa • Eprazinone • Erdosteine • Letosteine • Mesna • Neltenexine • Sobrerol • Stepronin • Tiopronin

Cough suppressants

Opium alkaloids, Opioids, and derivatives	Acetyldihydrocodeine • Benzylmorphine • Codeine • Dextromethorphan • Heroin • Dihydrocodeine • Dimemorfan • Droxypropine • Ethylmorphine • Hydrocodone • Hydromorphone • Isoaminile • Laudanum • Levomethadone • Levopropoxyphene • Methadone • Nicocodeine • Nicodicodeine • Normethadone • Noscapine • Pholcodine • Thebacon • Tipepidine • Zipeprol

Other	Benzonatate • Benproperine • Bibenzonium bromide • Butamirate • Clobutinol • Clofedanol • Cloperastine • Diphenhydramine • Dibunate • Dimethoxanate • Dropropizine • Fedrilate • Glaucine • Levodropropizine • Meprotixol • Morclofone • Nepinalone • Oxolamine • Oxeladin • Pentoxyverine • Pipazetate • Prenoxdiazine • Piperidione

Hallucinogens

Psychedelics
5-HT_2AR Agonists

Lysergamides: AL-LAD • ALD-52 • BU-LAD • CYP-LAD • Diallyllysergamide • DAM-57 • Ergonovine • ETH-LAD • LAE-32 • LSD • LPD-824 • LSM-775 • D-Lysergic acid N-(α-hydroxyethyl)amide • Lysergic acid 2-butyl amide • Lysergic acid 2,4-dimethylazetidide • Methylergonovine • Methylisopropyllysergamide • MLD-41 • PARGY-LAD • PRO-LAD • Phenethylamines: Aleph • 2C-B • 2C-B-FLY • 2CBFly-NBOMe • 2C-C • 2C-D • 2C-E • 2C-F • 2C-G • 2C-I • 2C-N • 2C-O • 2C-O-4 • 2C-P • 2C-T • 2C-T-2 • 2C-T-4 • 2C-T-7 • 2C-T-8 • 2C-T-9 • 2C-T-13 • 2C-T-15 • 2C-T-17 • 2C-T-21 • 2C-TFM • 2C-YN • 2CBCB-NBOMe • 25B-NBOMe • 25I-NBMD • 25I-NBOH • 25I-NBOMe • 3C-E • 3C-P • Br-DFLY • DESOXY • DMMDA-2 • DOB • DOC • DOET • DOI • DOM • DON • DOPR • DOTFM • Escaline • Ganesha • HOT-2 • HOT-7 • HOT-17 • Isoproscaline • Jimscaline • Lophophine • MDA • MDEA • MDMA • MMDA • MMDA-2 • MMDA-3a • MMDMA • Macromerine • Mescaline • Methallylescaline • Myristicin • Proscaline • TCB-2 • TFMFly • TMA; Piperazines: pFPP • TMFPP; Tryptamines: 1-Methyl-5-methoxy-diisopropyltryptamine • 2,N,N-TMT • 4,N,N-TMT • 4-HO-5-MeO-DMT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-Acetoxy-DPT • 4-Acetoxy-MiPT • 4-HO-DPT • 4-HO-MET • 4-Propionyloxy-DMT • 4-Hydroxy-N-Methyl-(α,N-trimethylene)tryptamine • 5-Me-MIPT • 5-N,N-TMT • 5-AcO-DMT • 5-MeO-2,N,N-TMT • 5-MeO-4,N,N-TMT • 5-MeO-α,N,N-TMT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-EiPT • 5-MeO-MET • 5-MeO-MIPT • 5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine • 7,N,N-TMT • α,N,N-TMT • α-ET • α-MT • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • Ethocin • Ethocybin • Iprocin • MET • Miprocin • MIPT • Norbaeocystin • PiPT • Psilocin • Psilocybin; Others: AL-34662 • AL-37350A • AL-38022A • Ibogaine • Noribogaine • Voacangine

Dissociatives
NMDAR Antagonists

Adamantanes: Amantadine • Memantine • Rimantadine; Arylcyclohexylamines: Dieticyclidine • Esketamine • Eticyclidine • Gacyclidine • Ketamine • Neramexane • Phencyclidine • Rolicyclidine • Tenocyclidine • Tiletamine; Morphinans: Dextromethorphan • Dextrorphan • Methorphan / Racemethorphan • Morphan / Racemorphan; Others: 2-MDP • 8A-PDHQ • Aptiganel • Dexoxadrol • Dizocilpine / MK-801 • Etoxadrol • Ibogaine • Midafotel • NEFA • Nitrous Oxide • Noribogaine • Perzinfotel • Remacemide • Selfotel • Xenon

Deliriants
mAChR Antagonists

3-Quinuclidinyl benzilate • Atropine • Benactyzine • Benzatropine • Benzydamine • Biperiden • Brompheniramine • CAR-226,086 • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • Chlorpheniramine • Chloropyramine • Clemastine • CS-27349 • Cyclizine • Cyproheptadine • Dicyclomine / Dicycloverine • Dimenhydrinate • Diphenhydramine • Ditran • Doxylamine • EA-3167 • EA-3443 • EA-3580 • EA-3834 • Flavoxate • Hydroxyzine • Hyoscyamine • Meclizine • N-Ethyl-3-piperidyl benzilate • N-Methyl-3-piperidyl benzilate • Pyrilamine • Orphenadrine • Oxybutynin • Pheniramine • Phenyltoloxamine • Procyclidine • Promethazine • Scopolamine / Hyoscine • Tolterodine • Trihexyphenidyl • Tripelennamine • Triprolidine • WIN-2299

Miscellaneous
Atypicals

Cannabinoids CB₁R Agonists	Cannabinol • CP-47,497 • CP-55,244 • CP-55,940 • DMHP • HU-210 • JWH-018 • JWH-030 • JWH-073 • JWH-081 • JWH-200 • JWH-250 • Nabilone • Nabitan • Nantradol • Parahexyl • THC / Dronabinol • WIN-55,212-2

Inhalants Mixed MOA	Acetone • Butane • Chloroform • Diethyl Ether / Ether • Enflurane • Freon • Gasoline / Petrol • Kerosene / Paraffin • Propane

Narcotics κOR Agonists	2-EMSB • 2-MMSB • Alazocine • Bremazocine • Butorphanol • Cyclazocine • Cyprenorphine • Dezocine • Enadoline • Herkinorin • HZ-2 • Ibogaine • Ketazocine • Metazocine • Nalbuphine • Nalorphine • Noribogaine • Pentazocine • Phenazocine • Salvinorin A • Spiradoline • Tifluadom • U-50488

Tranquilizers GABA_AR Agonists	Eszopiclone • Gaboxadol • Ibotenic Acid • Muscimol • Zaleplon • Zolpidem • Zopiclone

Others	Cryogenine / Sinicuichi • Efavirenz • Glaucine • Isoaminile • Narcotine / Noscapine

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Dextrorphan

Contents

Pharmacology

Legality

See also

References