n.
An anthelmintic agent, C16H29O8N3, used especially in the treatment of ascariasis and filariasis.
[DI-1 + ETHYL + CARBAM(IC ACID) + (PIPER)AZINE.]
diethylcarbamazine citrate
Dictionary:
di·eth·yl·car·bam·a·zine citrate (dī-ĕth'əl-kär-băm'ə-zēn') 
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n.
An anthelmintic agent, C16H29O8N3, used especially in the treatment of ascariasis and filariasis.
| 5min Related Video: diethylcarbamazine citrate |
| Veterinary Dictionary: diethylcarbamazine |
An antifilarial agent used in dogs as the citrate salt for the prevention of heartworm. Used also for the treatment of ascarids in dogs and immature lungworms in cattle and sheep.
| Wikipedia: Diethylcarbamazine |
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| Systematic (IUPAC) name | |
|---|---|
| N,N-diethyl-4-methylpiperazine-1-carboxamide | |
| Identifiers | |
| CAS number | 90-89-1 |
| ATC code | P02CB02 QP52 |
| PubChem | 3052 |
| DrugBank | APRD00918 |
| ChemSpider | 2944 |
| Chemical data | |
| Formula | C10H21N3O |
| Mol. mass | 199.293 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | . |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Legal |
| Routes | ? |
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Diethylcarbamazine (DEC) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.
Uses
DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.
In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because of the intense and unbearable itching associated with the dead subcutaneous parasites.
DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.
Mechanism
DEC is an inhibitor of arachidonic acid metabolism in filarial microfilaria. This makes the microfilaria more susceptible to immune attack.
Trade names
- Hetrazan
- Carbilazine
- Caricide
- Cypip
- Ethodryl
- Notézine
- Spatonin
- Filaribits
- Banocide Forte
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Copyrights:
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 | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Diethylcarbamazine". Read more |
