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trade name: Dolobid; drug class: salicylate derivative, nonsteroidal antiinflammatory; action: inhibits prostaglandin synthesis; uses: mild-to-moderate pain, symptoms of rheumatoid arthritis and osteoarthritis.
Diflunisal
| Dental Dictionary: diflunisal |
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| Drug Info: Diflunisal |
Brand names: Dolobid®
Chemical formula:
- Drug Forms:
- Diflunisal tablets (below)
- Diflunisal Oral tablet
Diflunisal tablets
What are diflunisal tablets?
DIFLUNISAL (Dolobid®) reduces the joint pain, stiffness, inflammation, or swelling caused by rheumatoid arthritis (rheumatism) and osteoarthritis. It also relieves mild to moderate pain. Generic diflunisal tablets are available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• anemia
• asthma, especially aspirin sensitive asthma
• bleeding disorders, such as hemophilia
• cigarette smoker
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• dental disease
• diabetes
• heart or circulation problems like angina, high blood pressure, heart failure, heart rhythm problems, history of heart attack, history of blood clots, or leg edema (fluid retention) • if you drink more than three (3) alcohol-containing beverages a day
• kidney disease
• liver disease
• stomach or duodenal ulcers
• history of stroke
• systemic lupus erythematosus
• taking medicines that make you bleed easily such as anticoagulants ('blood thinners')
• ulcerative colitis
• an unusual or allergic reaction to diflunisal, aspirin, other salicylates, other NSAIDs, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take diflunisal tablets by mouth. Follow the directions on the prescription label. Swallow the tablets whole with a full glass of water. You may take diflunisal with milk or food if it upsets your stomach. Take your doses at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What drug(s) may interact with diflunisal?
• alcohol
• alendronate
• aspirin and aspirin-like medicines
• cidofovir
• cyclosporine
• drospirenone; ethinyl estradiol (Yasmin®)
• herbal products that contain feverfew, garlic, ginger, or ginkgo biloba
• lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots such as warfarin and other 'blood thinners'
• methotrexate
• other antiinflammatory drugs (such as ibuprofen or prednisone)
• water pills (diuretics)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking diflunisal?
Let your prescriber or health care professional know if your pain continues, do not take with other pain medicine without advice. If you get flu-like symptoms (fever, chills, muscle aches, and pains), call your prescriber or health care professional; do not treat yourself.
To reduce unpleasant effects on your throat and stomach, take diflunisal with a full glass of water and never just before lying down. If you notice black, tarry stools or experience severe stomach pain and vomit blood or what looks like coffee grounds, notify your health care prescriber immediately.
If you are taking medicines that affect the clotting of your blood, such as aspirin or blood thinners such as Coumadin®, talk to your health care provider or prescriber before taking this medicine.
Limit smoking of cigarettes or drinking of alcohol. Smoking cigarettes or drinking alcohol may increase irritation to your stomach and can make it more susceptible to adverse reactions from diflunisal.
If you are going to have surgery or dental work, tell your prescriber or health care professional that you are taking diflunisal.
It is especially important not to use diflunisal during the last 3 months of pregnancy unless specifically directed to do so by your health care provider. Diflunisal may cause problems in the unborn child or complications during delivery.
What side effects may I notice from taking diflunisal?
Elderly patients are at increased risk for developing side effects.
Side effects that you should report to your prescriber or health care professional as soon as possible:
• signs of bleeding from the stomach - black tarry stools, blood in the urine, unusual tiredness or weakness, vomiting blood or vomit that looks like coffee grounds
• signs of an allergic reaction - difficulty breathing or wheezing, skin rash, redness, blistering or peeling skin, hives, or itching, swelling of eyelids, throat, lips
• blurred vision
• change in the amount of urine passed
• difficulty swallowing, severe heartburn or burning, pain in throat
• pain or difficulty passing urine
• stomach pain or cramps
• swelling of feet or ankles
• yellowing of eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation
• diarrhea
• dizziness
• drowsiness
• gas
• headache
• heartburn
• nausea, vomiting
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Veterinary Dictionary: diflunisal |
A salicylic acid derivative that, like aspirin, has analgesic and anti-inflammatory properties.
| Wikipedia: Diflunisal |
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Diflunisal
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| Systematic (IUPAC) name | |
| 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid | |
| Identifiers | |
| CAS number | 22494-42-4 |
| ATC code | N02BA11 |
| PubChem | 3059 |
| DrugBank | APRD00922 |
| ChemSpider | 2951 |
| Chemical data | |
| Formula | C13H8F2O3 |
| Mol. mass | 250.198 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | 80-90% |
| Protein binding | >99% |
| Metabolism | Hepatic |
| Half life | 8 to 12 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
 (what is this?) (verify) |
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'Diflunisal' is a generic NSAID (non-steroidal anti-inflammatory drug). It was developed by Merck Sharp & Dohme in 1971 after showing promise in a research project studying more potent chemical analogs of aspirin.[1] It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available. It is available in 250 mg and 500 mg tablets.
Contents |
Mechanism
Like all NSAIDs, Diflunisal acts by inhibiting the production of prostaglandin [2], a hormone which is involved in inflammation and pain. There is also an antipyretic effect, but this is not a recommended use of the drug. Though diflunisal has an onset of 1 hour, and maximum analgesia at 2 to 3 hours, the diflunisal plasma levels will not be steady until repeated doesages are achieved. The long plasma half-life is a distinctive feature of diflunisal in comparison to similar drugs. To increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. It is primarily used to treat symptoms of arthritis, and for acute pain following oral surgery, especially removal of wisdom teeth.
Side Effects
The inhibition of prostaglandins also has the effect of decreasing the protection given to the stomach from its own acid. Like all NSAIDS, this leads to an increased risk of stomach ulcers, and their complications, with long-term use.
Overdose
Deaths that have occurred from diflunisal usually involved mixed drugs and or extremely high dosage. The oral LD50 is 500 mg/kg. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500 mg, thus it is relatively hard to overdose by accident.
Abuse
This medication is unlikely to be abused: it has no effects in common with recreational drugs. However, a few people with psychological disturbances are susceptible to abusing medication of any kind.[citation needed]
Indicated for:
Do not cut/crush/chew. Monitor blood pressure. Use lowest effective dose for shortest duration. |
Side effects:
Eye:
Skin:
Precautions:
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References
- ^ Ibuprofen, the propionics and NSAIDs: Personal reflections over four decades Inflammopharmacology, Volume 7, Number 3 / September, 1999 url=http://www.springerlink.com/index/X417H50243123X78.pdf retrieved Aug 12, 2009 doi:10.1007/s10787-999-0002-3
- ^ Physiol. Rev. 88: 1547-1565, 2008; doi:10.1152/physrev.00004.2008
External links
- http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a684037.html
- http://www.medsafe.govt.nz/Profs/Datasheet/discontinued/ansaltab.htm
- Dolobid Prescribing Information (manufacturer's website)
- Dolobid Medication Guide (manufacturer's website)
- Diflunisal (patient information)
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| Tabletas de diflunisal |
| Diflunisal Oral tablet |
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 | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Diflunisal". Read more |
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