Brand names: Cervidil™Prepidil®Prostin E2®
Chemical formula:
- Drug Forms:
- Dinoprostone, Prostaglandin E2 vaginal suppositories (below)
- Dinoprostone Vaginal suppository
- Dinoprostone Vaginal gel
- Dinoprostone Vaginal insert
- Español:
- Supositorios vaginales de dinoprostona, prostaglandina E2
- Dinoprostona, Supositorio vaginal
- Dinoprostona, Gel vaginal
- Dinoprostona, Inserto vaginal
Dinoprostone, Prostaglandin E2 vaginal suppositories
What are dinoprostone vaginal suppositories?
DINOPROSTONE, PROSTAGLANDIN E2 (Prostin E2®) stimulates contractions to empty the uterus after an incomplete abortion or miscarriage, or when fetal death occurs. Dinoprostone is used when necessary to induce abortion between the 12th and 20th week of pregnancy, as calculated from the first day of the last normal menstrual period. Dinoprostone is also used for a condition called hydatidiform mole. Generic dinoprostone vaginal suppositories are not yet available.What should I tell my health care provider before I take this medicine?
They need to know if you have any of the following conditions:• anemia
• asthma
• diabetes
• heart, liver, lung, or kidney disease
• high or low blood pressure
• seizure disorder (convulsions)
• uterine surgery
• vaginal inflammation or infection
• an unusual or allergic reaction to dinoprostone, prostaglandins, other medicines, foods, dyes, or preservatives
How should I use this medicine?
A dinoprostone vaginal suppository is inserted high in the vagina by a health-care professional in a hospital or clinic setting. Remove the foil wrapping before use. After insertion of the suppository remain lying down for ten minutes. Further doses can be used at intervals of 3 to 5 hours, until the prostaglandin is effective. Prostaglandin should not be used for more than 2 days.Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
This does not apply.What drug(s) may interact with dinoprostone?
• oxytocinTell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking dinoprostone?
Your condition will be closely monitored while you use dinoprostone.Dinoprostone can make other muscles outside the uterus contract and cause side effects. Most of these effects will go away quickly. Contact your prescriber or health care professional at once if you get an unpleasant vaginal discharge, continued fever, chills and shivering, or increase in vaginal bleeding several days after treatment.
What side effects may I notice from using dinoprostone?
Side effects that you should report to your prescriber or health care professional as soon as possible:• chest pain or tightness in the chest
• continuous or excessive vaginal bleeding
• fast or irregular heartbeat (palpitations)
• lightheadedness or fainting spells
• pale, cool, blotchy skin
• pelvic area pain
• skin rash or itching (hives)
• stomach pain, or severe cramping pains
• unusual swelling of the face, nose, or eyelids
• wheezing or difficulty breathing
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• dizziness
• fever
• flushing of the skin
• headache
• nausea, vomiting
Where can I keep my medicine?
Keep out of the reach of children.Store in a freezer below —20 degrees C (—4 degrees F). Restore to room temperature immediately before use. Throw away any unused suppositories after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
