Disopyramide

Disopyramide
Systematic (IUPAC) name
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
Identifiers
CAS number	3737-09-5
ATC code	C01BA03
PubChem	3114
DrugBank	APRD00507
ChemSpider	3002
Chemical data
Formula	C21H29N3O
Mol. mass	339.475 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Therapeutic considerations
Pregnancy cat.	B2(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, intravenous
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Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

Cardiac Adverse Effects

• Acute heart failure[1]
• Severe hypotension

Extracardiac Effects

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Glaucoma
• Rash
• Agranulocytosis

External links

• Disopyramide on RxList

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