Dopexamine

Dopexamine

Systematic (IUPAC) name
4-[2-({6-[(2-phenylethyl)amino]hexyl}amino)ethyl]benzene-1,2-diol
Identifiers
CAS number	86197-47-9
ATC code	C01CA14
PubChem	55483
Chemical data
Formula	C22H32N2O2
Mol. mass	429.43 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Dopexamine is a β₂-adrenergic receptor agonist. It also acts at dopamine receptors.^[1]

Use in sepsis has been proposed.^[2]

It is considered a inotropic agent.^[3]

References

1. ^ Brown RA, Dixon J, Farmer JB, et al. (July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". Br. J. Pharmacol. 85 (3): 599–608. PMID 2862944. 
2. ^ Birnbaum J, Klotz E, Spies CD, et al. (2006). "Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats". Crit Care 10 (4): R117. doi:10.1186/cc5011. PMID 16893450. PMC 1750974. http://ccforum.com/content/10/4/R117. 
3. ^ Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?". Chest 123 (5 Suppl): 460S–3S. doi:10.1378/chest.123.5_suppl.460S. PMID 12740229. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=12740229. 

v • d • e Cardiac stimulants excluding cardiac glycosides (C01C) Adrenergic and dopaminergic agents Adrenergic agonists α Metaraminol • Phenylephrine • Methoxamine • Norfenefrine • Oxedrine • Midodrine • Mephentermine β Dobutamine • Arbutamine • Isoprenaline • Prenalterol mixed Epinephrine # • Norepinephrine • Etilefrine Dopamine agonists Fenoldopam Both Dopamine # • Dopexamine • Ibopamine • Octopamine Unknown/ungrouped Dimetofrine • Gepefrine • Cafedrine • Theodrenaline Phosphodiesterase inhibitors (PDE3I) Amrinone • Milrinone • Enoximone • Bucladesine Other cardiac stimulants Angiotensinamide • Xamoterol • Levosimendan # = WHO-EM

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