| Galactitol | |
|---|---|
 |
|
| IUPAC name |
(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol
|
| Other names | D-galactitol |
| Identifiers | |
| CAS number | 608-66-2  |
| PubChem | 11850 |
| SMILES |
C([C@H]([C@@H]([C@@H]([C@H](CO)O)O)O)O)O
|
| Properties | |
| Molecular formula | C6H14O6 |
| Molar mass | 182.17 g mol−1 |
| (what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Dulcitol (or galactitol) is a sugar alcohol, the reduction product of galactose.[1] In people with galactokinase deficiency, a form of galactosemia, excess dulcitol formation in the lens of the eye leads to cataracts.[2]
Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.
The other common galactose metabolism defect is a defect in galactose-1-phosphate uridyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. The toxicity associated with galactose-1-phosphate uridyltransferase deficiency is associated with symptoms of hepatosplenomegaly and mental retardation in addition to the cataracts caused by galactitol buildup.
References
- ^ "dulcitol - Compound Summary". National Center for Biotechnology Information. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11850. Retrieved 2008-08-06.
- ^ Roth, KS (September 10, 2007). "Galactokinase Deficiency". eMedicine. WebMD. http://www.emedicine.com/ped/TOPIC815.HTM. Retrieved 2008-08-08.
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