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Epstein-Barr virus induced gene 3
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| Identifiers | ||||||||||||||
| Symbols | EBI3; | |||||||||||||
| External IDs | OMIM: 605816 MGI: 1354171 HomoloGene: 4207 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 10148 | 50498 | ||||||||||||
| Ensembl | ENSG00000105246 | ENSMUSG00000003206 | ||||||||||||
| Uniprot | Q14213 | Q3U1K3 | ||||||||||||
| Refseq | NM_005755 (mRNA) NP_005746 (protein) |
NM_015766 (mRNA) NP_056581 (protein) |
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| Location | Chr 19: 4.18 - 4.19 Mb | Chr 17: 55.55 - 55.55 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Epstein-Barr virus induced gene 3, also known as EBI3, is a protein which in humans is encoded by the EBI3 gene.[1][2]
Function
This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[3]
EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[4] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[5][3]
References
- ^ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10148.
- ^ Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. PMID 8551575. PMC: 189923. http://jvi.asm.org/cgi/content/abstract/70/2/1143.
- ^ a b Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature 450 (7169): 566–9. doi:. PMID 18033300.
- ^ Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:. PMID 16906167.
- ^ Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:. PMID 17874423.
Further reading
- Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2.". N. Engl. J. Med. 295 (7): 397. PMID 934235.
- Devergne O, Hummel M, Koeppen H, et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.". J. Virol. 70 (2): 1143–53. PMID 8551575.
- Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041–6. doi:. PMID 9342359.
- Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779–90. doi:. PMID 12121660.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases.". J. Pathol. 202 (2): 164–71. doi:. PMID 14743498.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:. PMID 15057824.
- Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease.". J. Med. Virol. 73 (3): 432–8. doi:. PMID 15170639.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:. PMID 16189514.
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