EIF4A2

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Eukaryotic translation initiation factor 4A, isoform 2
Identifiers
Symbols	EIF4A2; EIF4A; BM-010; DDX2B; EIF4F
External IDs	OMIM: 601102 MGI: 106906 HomoloGene: 1487
Gene ontology Molecular function • nucleotide binding • nucleic acid binding • RNA binding • translation initiation factor activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity Cellular component • eukaryotic translation initiation factor 4F complex Biological process • translation • regulation of translational initiation
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1974	13682
Ensembl	ENSG00000156976	ENSMUSG00000022884
UniProt	Q14240	Q52KC1
RefSeq	NM_001967 (mRNA)	NM_013506 (mRNA)
	NP_001958 (protein)	NP_038534 (protein)
Location	Chr 3: 187.98 - 187.99 Mb	Chr 16: 23.02 - 23.03 Mb
PubMed search	[1]	[2]

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.^[1][2]

References

1. ^ Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet 71 (4): 385-8. PMID 8521730. 
2. ^ "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1974. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.". J. Biol. Chem. 276 (31): 29111–5. doi:10.1074/jbc.C100284200. PMID 11408474. 
• Kyono K, Miyashiro M, Taguchi I (2002). "Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro.". Biochem. Biophys. Res. Commun. 292 (3): 659–66. doi:10.1006/bbrc.2002.6702. PMID 11922617. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Sarkar M, Das S, Bandyopadhaya A, et al. (2005). "Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis.". FEBS Lett. 579 (16): 3449–60. doi:10.1016/j.febslet.2005.05.012. PMID 15946665. 
• Feng P, Everly DN, Read GS (2005). "mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.". J. Virol. 79 (15): 9651–64. doi:10.1128/JVI.79.15.9651-9664.2005. PMID 16014927. 
• Cheyssac C, Dina C, Leprêtre F, et al. (2006). "EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.". Diabetes 55 (4): 1171–6. doi:10.2337/diabetes.55.04.06.db05-1298. PMID 16567544. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 

v • d • e Protein biosynthesis: translation (prokaryotic, eukaryotic) Ribosomal proteins Initiation factor Prokaryotic PIF-1 · PIF-2 · PIF-3 Archaeal aIF1 aIF2 aIF5 aIF6 Eukaryotic eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, 5B) eIF6 Elongation factor Prokaryotic (EF-Tu, EF-Ts, EF-G)  · Archaeal (aEF-1, aEF-2)  · Eukaryotic (EEF-1, EEF-2) Release factor Prokaryotic · Archaeal · Eukaryotic Other Ribosomal protein s6 Other concepts Aminoacyl tRNA synthetase · Reading frame · Start codon · Shine-Dalgarno sequence/Kozak consensus sequence

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