| Endocardial cushions | |
|---|---|
 |
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| Interior of dorsal half of heart from a human embryo of about thirty days. | |
| Gray's | subject #135 512 |
| Carnegie stage | 14 |
| Days | 27 |
| Precursor | neural crest[1] |
| Gives rise to | septum intermedium |
Endocardial cushions refers to a subset of cells in the primordial heart that play a vital role in proper heart septation.
They develop on the atrioventricular canal.[2]
During development the heart starts out as a tube. As heart development continues this tube undergoes conformational changes and remodeling to eventually form the four-chambered heart. The endocardial cushions are a subset of cells found in the developing heart tube that will give rise to the heart's valves and septa critical to the proper formation of a four-chambered heart.
Contents |
Clinical significance
A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect.
Development
The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). These migrated cells form the "swelling" seen in the heart tube that is termed endocardial cushions
Upon sectioning of the heart the atrioventricular cushions can be observed in the lumen of the atrial canal as two thickenings, one on its dorsal and another on its ventral wall. These thickenings or endocardial cushions will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart.
See also
References
- ^ Maschhoff KL, Baldwin HS (2000). "Molecular determinants of neural crest migration". Am. J. Med. Genet. 97 (4): 280–8. doi:. PMID 11376439.
- ^ endocardial cushions at Dorland's Medical Dictionary
External links
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This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated.
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