A nonflammable liquid, C3H2ClF5O, used as an inhalant anesthetic.
[EN-1 + FLU(O)R(O)- + (ETH)ANE.]
Dictionary:
en·flur·ane (ĕn-flʊr'ān') ![]() |
[EN-1 + FLU(O)R(O)- + (ETH)ANE.]
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| Dental Dictionary: enflurane |
A nonflammable anesthetic gas belonging to the ether family, used for induction and maintenance of general anesthesia.
| Drug Info: Enflurane |
Brand names: Compound 347Ethrane®
Chemical formula:

Enflurane inhalation liquid
What is enflurane inhalation liquid?
ENFLURANE (Ethrane®) is used for general anesthesia during surgery and cesarean section. In addition to controlling pain and making you unconscious, general anesthesia control the body's reaction to stress and relieves fear and anxiety associated with surgery. You may receive more than one kind of anesthesia during your surgery or procedure. General anesthesia is commonly used for extensive and long surgeries, but also can be used in shorter and limited procedures. Generic enflurane inhalation liquid is available.What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:How should I use this medicine?
Enflurane is given through inhalation (breathing the gas into the lungs) by trained anesthesia professionals in a controlled environment like an operating room before and during surgery or procedures. Since there is no one ideal general anesthetic, a combination of drugs that are either injected or inhaled are typically used.What if I miss a dose?
This does not apply.What drug(s) may interact with enflurane?
alcoholWhat should I watch for while taking enflurane?
You will be closely monitored following anesthesia with enflurane.What side effects may I notice from using enflurane?
During your surgery or procedure the anesthesiologist will closely monitory all your body systems and treat any serious side effects. Side effects that you should report to your prescriber or health care professional as soon as possible:Where can I keep my medicine?
You will only receive this medicine before surgery or other procedures.Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Veterinary Dictionary: enflurane |
A fluorinated ether, similar in action to halothane, used for general inhalation anesthesia.
| Wikipedia: Enflurane |
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Enflurane
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| Systematic (IUPAC) name | |
| 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C3H2ClF5O |
| Mol. mass | 184.492 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 97% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.
| Property | Value |
|---|---|
| Boiling point at 1 atm | 56.5 °C |
| MAC | 1.68 |
| Vapor pressure at 20 °C | 22.9 kPa (172 mm Hg) |
| Blood: Gas Partition Coefficient | 1.9 |
| Oil: Gas Partition Coefficient | 98 |
Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.
Enflurane also lowers the threshold for seizures and should especially not be used on people with epilepsy. It is also known to cause malignant hyperthermia.
Relaxes the uterus in pregnant women.
Enflurane and Methoxyflurane have a nephrotoxic effect and cause acute renal failure usually by its nephrotoxic metabolite. By G. Edward Morgan, Maged S. Mikhail, Michael J. Murray, C. Philip Larson; clinical anaesthesiology third edition,142.
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| Enflurane inhalation liquid | |
| anesthetic | |
| Anesthesia, General |
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