any pentapeptide
endorphin with the sequence Tyr-Gly-Gly-Phe-Xaa. There are two similar naturally occurring enkephalins, present in brain, spinal cord, and gut; their recommended trivial names are: [5-leucine]enkephalin (
abbr.: [Leu
5]enkephalin
or [Leu]enkephalin), Tyr-Gly-Gly-Phe-Leu (I); and [5-methionine]enkephalin (
abbr.: [Met
5]enkephalin
or [Met]enkephalin), Tyr-Gly-Gly-Phe-Met (II). (II has the same sequence as residues 61 — 65 of β-
lipotropin.) The common precursor of I and II, proenkephalin — itself formed from preproenkephalin by removal of the signal peptide — contains four copies of II and one each of I, the heptapeptide [Met
5]enkephalinyl-Arg-Phe, and the octapeptide [Met
5]enkephalinyl-Arg-Phe-Leu. (
Note: Designations such as Leu-, leucyl-, or leucine-enkephalin have commonly been given to I, with corresponding terms for II, but all of these incorrectly imply N-terminal extension with a residue of leucine or methionine, respectively.)