Enoximone

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Enoximone
Systematic (IUPAC) name
4-methyl-5-{[4-(methylsulfanyl)phenyl]carbonyl}-2,3-dihydro-1H-imidazol-2-one
Identifiers
CAS number	77671-31-9
ATC code	C01CE03
PubChem	53708
Chemical data
Formula	C12H12N2O2S
Mol. mass	248.302 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	50% (oral)
Protein binding	85%
Metabolism	Hepatic oxidation
Half life	4 to 10 hours
Excretion	Renal (60 to 70%)
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Intravenous
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Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. Selective for phosphodiesterase 3

v • d • e Phosphodiesterase inhibitors (C01CE, G04BE) PDE1 MMPX • SCH-51866 • Vinpocetine PDE2 BAY 60-7550 • EHNA PDE3 Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • RPL-554 • Siguazodan • Trequinsin • Zardaverine PDE4 Arofylline • Cilomilast • CP-80633 • Denbutylline • Drotaverine • Etazolate • Glaucine • HT-0712 • Ibudilast • ICI-63197 • Irsogladine • Mesembrine • Pentoxifylline • Propentofylline • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976 PDE5 Acetildenafil • Avanafil • Dipyridamole • Icariin • Lodenafil • Mirodenafil • MY-5445 • Sildenafil • T-0156 • Tadalafil • Thiomethisosildenafil • Udenafil • Vardenafil PDE6 Zaprinast PDE7 BRL-50481 PDE9 BAY 73-6691 • SCH-51866 PDE10 Papaverine • PF-2545920 • Tofisopam Nonselective Caffeine • Theophylline  • IBMX • Doxofylline

v • d • e Cardiac stimulants excluding cardiac glycosides (C01C) Adrenergic and dopaminergic agents Adrenergic agonists α Metaraminol • Phenylephrine • Methoxamine • Norfenefrine • Oxedrine • Midodrine • Mephentermine β Dobutamine • Arbutamine • Isoprenaline • Prenalterol mixed Epinephrine # • Norepinephrine • Etilefrine Dopamine agonists Fenoldopam Both Dopamine # • Dopexamine • Ibopamine • Octopamine Unknown/ungrouped Dimetofrine • Gepefrine • Cafedrine • Theodrenaline Phosphodiesterase inhibitors (PDE3I) Amrinone • Milrinone • Enoximone • Bucladesine Other cardiac stimulants Angiotensinamide • Xamoterol • Levosimendan # = WHO-EM

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