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Entactin

 
Veterinary Dictionary: entactin
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An adhesive glycoprotein contributing to the cell-to-basal membrane and lamina-to-matrix interfaces.

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Wikipedia: Entactin
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Nidogen 1
PBB Protein NID1 image.jpg
PDB rendering based on 1gl4.
Available structures
1gl4, 1h4u
Identifiers
Symbols NID1; NID
External IDs OMIM: 131390 MGI: 97342 HomoloGene: 1878
RNA expression pattern
PBB GE NID1 202008 s at tn.png
PBB GE NID1 202007 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4811 18073
Ensembl ENSG00000116962 n/a
UniProt P14543 n/a
RefSeq NM_002508 (mRNA) NM_010917 (mRNA)
NP_002499 (protein) NP_035047 (protein)
Location Chr 1:
234.21 - 234.3 Mb		 n/a
PubMed search [1] [2]

Entactin (or nidogen) is a component of the basement membrane alongside other components such as collagen type IV, proteoglycans ( heparan sulfate and glycosaminoglycans), laminin and fibronectin.

This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix.[1]

Contents

Interactions

Entactin has been shown to interact with FBLN1.[2][3][4]

References

  1. ^ "Entrez Gene: NID1 nidogen 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4811. 
  2. ^ Adam, S; Göhring W, Wiedemann H, Chu M L, Timpl R, Kostka G (Sep. 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. (ENGLAND) 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. ISSN 0022-2836. PMID 9299350. 
  3. ^ Tran, H; VanDusen W J, Argraves W S (Sep. 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. (UNITED STATES) 272 (36): 22600–6. ISSN 0021-9258. PMID 9278415. 
  4. ^ Pan, T C; Kluge M, Zhang R Z, Mayer U, Timpl R, Chu M L (Aug. 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. (GERMANY) 215 (3): 733–40. ISSN 0014-2956. PMID 8354280. 

Further reading

  • Chung AE, Durkin ME (1990). "Entactin: structure and function.". Am. J. Respir. Cell Mol. Biol. 3 (4): 275–82. PMID 2119632. 
  • Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes.". FASEB J. 4 (6): 1577–90. PMID 2180767. 

External links

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Learn More
Fibrinogen beta chain
Fibrinogen alpha chain
Laminin

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Copyrights:

Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Entactin".  Read more