EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.[1][2][3]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[3]
Interactions
EPH receptor A3 has been shown to interact with EFNB2[4][5] and EFNA5.[6][5]
References
- ^ Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (Mar 1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line". J Biol Chem 267 (5): 3262–7. PMID 1737782.
- ^ Wicks IP, Wilkinson D, Salvaris E, Boyd AW (Apr 1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc Natl Acad Sci U S A 89 (5): 1611–5. PMID 1311845.
- ^ a b "Entrez Gene: EPHA3 EPH receptor A3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2042.
- ^ Cerretti, D P; Vanden Bos T, Nelson N, Kozlosky C J, Reddy P, Maraskovsky E, Park L S, Lyman S D, Copeland N G, Gilbert D J (Nov. 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. (ENGLAND) 32 (16): 1197–205. ISSN 0161-5890. PMID 8559144.
- ^ a b Lackmann, M; Mann R J, Kravets L, Smith F M, Bucci T A, Maxwell K F, Howlett G J, Olsson J E, Vanden Bos T, Cerretti D P, Boyd A W (Jun. 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". J. Biol. Chem. (UNITED STATES) 272 (26): 16521–30. ISSN 0021-9258. PMID 9195962.
- ^ Kozlosky, C J; VandenBos T, Park L, Cerretti D P, Carpenter M K (Aug. 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine (UNITED STATES) 9 (8): 540–9. doi:10.1006/cyto.1997.0199. ISSN 1043-4666. PMID 9245480.
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Ernst AF, Jurney WM, McLoon SC (1999). "Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide.". Prog. Brain Res. 118: 115–31. doi:10.1016/S0079-6123(08)63204-5. PMID 9932438.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
- Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.". Embo J. 13 (16): 3757–62. PMID 8070404.
- Wicks IP, Lapsys NM, Baker E, et al. (1994). "Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2.". Genomics 19 (1): 38–41. doi:10.1006/geno.1994.1009. PMID 8188238.
- Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.". Mol. Immunol. 32 (16): 1197–205. doi:10.1016/0161-5890(95)00108-5. PMID 8559144.
- Lackmann M, Mann RJ, Kravets L, et al. (1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor.". J. Biol. Chem. 272 (26): 16521–30. doi:10.1074/jbc.272.26.16521. PMID 9195962.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.". Cytokine 9 (8): 540–9. doi:10.1006/cyto.1997.0199. PMID 9245480.
- Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Lackmann M, Oates AC, Dottori M, et al. (1998). "Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization.". J. Biol. Chem. 273 (32): 20228–37. doi:10.1074/jbc.273.32.20228. PMID 9685371.
- Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID 9751130.
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2gsf: The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
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