Eprazinone

Eprazinone
Systematic (IUPAC) name
3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one
Identifiers
CAS number	?
ATC code	R05CB04
PubChem	3245
Chemical data
Formula	C24H32 = N=2O2
Mol. mass	380.523 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Eprazinone is a mucolytic.

From Merck Index:

Monograph Number: 3661 Title: Eprazinone CAS Registry Number: 10402-90-1 CAS Name: 3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone Additional Names: 3-[4-(b-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone Molecular Formula: C24H32N2O2 Molecular Weight: 380.52. Percent Composition: C 75.75%, H 8.48%, N 7.36%, O 8.41% Literature References: Prepn of the dihydrochloride: R. Y. Mauvernay, NL 6602581; idem, US 3448192 (1966, 1969 both to Riom). Pharmacodynamics: J. Vacher et al., Arch. Int. Pharmacodyn. Ther. 165, 1 (1967). Pharmacological study: Y. Kase et al., Nippon Yakurigaku Zasshi 73, 605 (1977), C.A. 88, 15657 (1978). Efficacy: W. Spitzer, Fortschr. Med. 98, 871 (1980). Metabolism: P. Toffel-Nadolny, W. Gielsdorf, Arzneimittel-Forsch. 31, 719 (1981).

Derivative Type: Dihydrochloride CAS Registry Number: 10402-53-6 Manufacturers' Codes: 746-CE Trademarks: Eftapan (Merckle); Mucitux (Riom) Molecular Formula: C24H32N2O2.2HCl Molecular Weight: 453.45. Percent Composition: C 63.57%, H 7.56%, N 6.18%, O 7.06%, Cl 15.64% Properties: White, bitter-tasting crystalline powder, mp 201° (Toffel-Nadolny, Gielsdorf); also reported as crystals from methanol, mp 160° (Mauvernay). LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher). Melting point: mp 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay) Toxicity data: LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)

Therap-Cat: Antitussive.

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