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etodolac

 
Dictionary: e·to·do·lac   (ĭ-tō'də-lăk) pronunciation
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n.
A nonsteroidal anti-inflammatory medication, used especially for the treatment of osteoarthritis.

[eto- (alteration of ETHYL) + (IN)DOL(E) + AC(ETIC ACID).]


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Dental Dictionary: etodolac
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n

trade name: Lodine; drug class: nonsteroidal antiinflammatory; action: inhibits prostaglandin synthesis by interfering with cyclooxgenase, which is needed for biosynthesis; uses: mild-to-moderate pain, osteoarthritis.

Drug Info: Etodolac
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Brand names: Lodine®Lodine® XL

Chemical formula:



Etodolac Oral capsule

What is this medicine?

ETODOLAC (ee toe DOE lak) is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat mild to moderate pain. This medicine may be used to treat osteoarthritis or rheumatoid arthritis.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• asthma
• coronary artery bypass graft (CABG) surgery within the past 2 weeks
• drink more than 3 alcohol containing drinks a day
• heart disease or circulation problems like heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach bleeding or ulcers
• an unusual or allergic reaction to etodolac, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
• cidofovir
• ketorolac
• methotrexate
• pemetrexed

This medicine may also interact with the following medications:
• alcohol
• aspirin and aspirin-like drugs
• cyclosporine
• digoxin
• diuretics
• lithium
• medicines for high blood pressure
• medicines that affect platelets
• medicines that treat or prevent blood clots like warfarin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• blurred vision
• chest pain
• difficulty breathing or wheezing
• fever
• nausea or vomiting
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• slurred speech or weakness on one side of the body
• unexplained weight gain or swelling
• unusual bleeding or bruising
• unusually weak or tired
• vomiting
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• diarrhea
• dizziness
• headache
• heartburn
• stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Veterinary Dictionary: etodolac
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A nonsteroidal anti-inflammatory COX-2 inhibitor used for its analgesic effect in dogs, primarily that associated with osteoarthritis.

Wikipedia: Etodolac
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Etodolac
Systematic (IUPAC) name
2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Identifiers
CAS number 41340-25-4
ATC code M01AB08
PubChem 3308
Chemical data
Formula C17H21NO3 
Mol. mass 287.35 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 145–148 °C (293–298 °F)
Solubility in water 3.92e-02 mg/mL [ALOGPS] mg/mL (20 °C)
Pharmacokinetic data
Bioavailability  ?
Protein binding 100%
Metabolism liver
Half life 7.3 ± 4.0 hours
Excretion renal
Therapeutic considerations
Pregnancy cat.

C
Legal status

POM(UK) ℞-only(US)
Routes oral
 Yes check.svgY(what is this?)  (verify)

Etodolac: Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin, Advil, Nuprin, etc.), naproxen (Aleve, Naprosyn), indomethacin (Indocin), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved etodolac in January 1991.[1]

It is an inhibitor of cyclooxygenase.[2]

Main article: NSAIDs

Contents

Preparations

Etodolac is manufactured by Shire under the trade name Lodine SR[3] and by Meda Pharmaceuticals under the name Eccoxolac [4]. Non-propriety etodolac is also available [5]

Indications

Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis [6]. It is increasingly being found in large seizures of heroin as an adulterant.

Dosing

Capsules: 200 and 300 mg; Tablets: 400 and 500 mg; Extended Release: 400, 500 and 600 mg [1]

Interactions

Etodolac should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can irritate both conditions. Etodolac is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Additionally, Etodolac has been found to interact with certain anti-depressant medications, such as sertraline or fluoxetine, can increase risks of stroke, heart attack, and other cardiovascular conditions. Patients also taking ciclosporin (Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of the procedure.

Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.

Box, strip and tablet of Etodolac (Lodine SR) 600mg

Pregnancy and Nursing

Etodolac is generally avoided during pregnancy and nursing.

Side Effects

Etodolac may cause side effects, or adverse drug reactions. Tell your doctor if any of these symptoms are severe or do not go away:

Constipation, diarrhea, gas or bloating, vomiting, headache, dizziness, ringing in the ears, runny nose, sore throat, blurred vision.

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more etodolac until you speak to your doctor:

Unexplained weight gain, swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs, fever or chills, blisters, rash, itching, hives, hoarseness, difficulty breathing or swallowing, yellowing of the skin or eyes, excessive tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, flu-like symptoms, pale skin, fast heartbeat, cloudy, discolored, or bloody urine, difficult or painful urination, back pain.

Etodolac may cause other side effects.

References

  1. ^ a b http://www.medicinenet.com/etodolac/article.htm
  2. ^ Sugimoto T, Aoyama M, Kikuchi K, et al. (2007). "Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis". Internal medicine (Tokyo, Japan) 46 (13): 1055–8. PMID 17603251. http://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/46.0094?from=PubMed. 
  3. ^ Summary of Product Characteristics Lodine SR
  4. ^ Summary of Product Characteristics Eccoxolac
  5. ^ BNF 55: Etodolac preparations
  6. ^ BNF 55 - Etodolac

External links

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Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Etodolac".  Read more