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Eukaryotic translation initiation factor 4 gamma

 
Wikipedia: Eukaryotic translation initiation factor 4 gamma
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Eukaryotic translation initiation factor 4 gamma, 1
PBB Protein EIF4G1 image.jpg
PDB rendering based on 1ug3.
Available structures
1ug3
Identifiers
Symbols EIF4G1; EIF4F; DKFZp686A1451; EIF4G; p220
External IDs OMIM: 600495 MGI: 2384784 HomoloGene: 28096
RNA expression pattern
PBB GE EIF4G1 208624 s at tn.png
PBB GE EIF4G1 208625 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1981 208643
Ensembl ENSG00000114867 ENSMUSG00000045983
UniProt Q04637 Q3UTK0
RefSeq NM_004953 (mRNA) NM_001005331 (mRNA)
NP_004944 (protein) NP_001005331 (protein)
Location Chr 3:
185.52 - 185.54 Mb		 Chr 16:
20.59 - 20.61 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.[1][2]

The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.[3]

Contents

Interactions

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,[4] EIF4A1,[5][6][7] EIF4E,[8][9][6][7][10] MKNK2[11] and PABPC1.[12]

References

  1. ^ Yan R, Rychlik W, Etchison D, Rhoads RE (Dec 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". J Biol Chem 267 (32): 23226–31. PMID 1429670. 
  2. ^ Imataka H, Sonenberg N (Dec 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Mol Cell Biol 17 (12): 6940–7. PMID 9372926. 
  3. ^ "Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1981. 
  4. ^ Pyronnet, S; Imataka H, Gingras A C, Fukunaga R, Hunter T, Sonenberg N (Jan. 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. (ENGLAND) 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMID 9878069. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  6. ^ a b Connolly, Eileen; Braunstein Steve, Formenti Silvia, Schneider Robert J (May. 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. (United States) 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. ISSN 0270-7306. PMID 16648488. 
  7. ^ a b Harris, Thurl E; Chi An, Shabanowitz Jeffrey, Hunt Donald F, Rhoads Robert E, Lawrence John C (Apr. 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMID 16541103. 
  8. ^ Vary, T C; Jefferson L S, Kimball S R (Dec. 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". Am. J. Physiol. (UNITED STATES) 277 (6 Pt 1): E1077-86. ISSN 0002-9513. PMID 10600798. 
  9. ^ Mader, S; Lee H, Pause A, Sonenberg N (Sep. 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4990–7. ISSN 0270-7306. PMID 7651417. 
  10. ^ Kumar, V; Sabatini D, Pandey P, Gingras A C, Majumder P K, Kumar M, Yuan Z M, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (Apr. 2000). "Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 275 (15): 10779–87. ISSN 0021-9258. PMID 10753870. 
  11. ^ Scheper, Gert C; Parra Josep L, Wilson Mary, Van Kollenburg Barbara, Vertegaal Alfred C O, Han Ze-Guang, Proud Christopher G (Aug. 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. (United States) 23 (16): 5692–705. ISSN 0270-7306. PMID 12897141. 
  12. ^ Imataka, H; Gradi A, Sonenberg N (Dec. 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. (ENGLAND) 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. ISSN 0261-4189. PMID 9857202. 

See also

Further reading

  • Gingras AC, Raught B, Sonenberg N (2000). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469. 
  • Yan R, Rhoads RE (1995). "Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that maps to chromosome 3q27-qter.". Genomics 26 (2): 394–8. doi:10.1016/0888-7543(95)80227-D. PMID 7601469. 
  • Mader S, Lee H, Pause A, Sonenberg N (1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.". Mol. Cell. Biol. 15 (9): 4990–7. PMID 7651417. 
  • Pause A, Belsham GJ, Gingras AC, et al. (1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.". Nature 371 (6500): 762–7. doi:10.1038/371762a0. PMID 7935836. 
  • Lamphear BJ, Yan R, Yang F, et al. (1993). "Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.". J. Biol. Chem. 268 (26): 19200–3. PMID 8396129. 
  • Haghighat A, Mader S, Pause A, Sonenberg N (1996). "Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.". Embo J. 14 (22): 5701–9. PMID 8521827. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Lamphear BJ, Rhoads RE (1997). "A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases.". Biochemistry 35 (49): 15726–33. doi:10.1021/bi961864t. PMID 8961935. 
  • Brass N, Heckel D, Sahin U, et al. (1997). "Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma.". Hum. Mol. Genet. 6 (1): 33–9. doi:10.1093/hmg/6.1.33. PMID 9002667. 
  • Eberle J, Krasagakis K, Orfanos CE (1997). "Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro.". Int. J. Cancer 71 (3): 396–401. doi:10.1002/(SICI)1097-0215(19970502)71:3<396::AID-IJC16>3.0.CO;2-E. PMID 9139875. 
  • Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334–42. PMID 9418880. 
  • Piron M, Vende P, Cohen J, Poncet D (1998). "Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.". Embo J. 17 (19): 5811–21. doi:10.1093/emboj/17.19.5811. PMID 9755181. 
  • Imataka H, Gradi A, Sonenberg N (1999). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.". Embo J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMID 9857202. 
  • Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.". Embo J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMID 9878069. 
  • Laroia G, Cuesta R, Brewer G, Schneider RJ (1999). "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.". Science 284 (5413): 499–502. doi:10.1126/science.284.5413.499. PMID 10205060. 
  • Vary TC, Jefferson LS, Kimball SR (2000). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle.". Am. J. Physiol. 277 (6 Pt 1): E1077–86. PMID 10600798. 
  • Cuesta R, Laroia G, Schneider RJ (2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.". Genes Dev. 14 (12): 1460–70. PMID 10859165. 
v • d • e
Protein biosynthesis: translation (prokaryotic, eukaryotic)
Ribosomal proteins
PIF-1 · PIF-2 · PIF-3
Archaeal
aIF1 aIF2 aIF5 aIF6

eIF1 (AX, AY, 1B)

eIF2 (α, β, γ)

eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6)

eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H)

eIF5 (A, A2, B)

eIF6
Prokaryotic (EF-Tu, EF-Ts, EF-G)  · Archaeal (aEF-1, aEF-2)  · Eukaryotic (EEF-1, EEF-2)
Prokaryotic · Archaeal · Eukaryotic
Other
Other concepts
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