exasperation

1. The act or an instance of exasperating.
2. The state of being exasperated; frustrated annoyance.

noun

1. The act of annoying: annoyance, botheration, bothering, harassment, irritation, pestering, provocation, vexation. See feelings, pain/pleasure.
2. The feeling of being annoyed: aggravation, annoyance, bother, botheration, irritation, vexation. See feelings, pain/pleasure.

Definition: upset
Antonyms: delight, pleasure

n

Definition: upset, provocation
Antonyms: calming, calmness, comfort, ease, placation, pleasing, soothing

The noun has 2 meanings:

Meaning #1: an exasperated feeling of annoyance
  Synonym: aggravation

Meaning #2: actions that cause great irritation (or even anger)

Quotes:

"Sir, you have tasted two whole worms; you have hissed all my mystery lectures and been caught fighting a liar in the quad; you will leave by the next town drain." - Rev. W. A. Spooner

"Your damned nonsense can I stand twice or once, but sometimes always, by God, never." - Hans Richter

"Lord Ronald said nothing; he flung himself from the room, flung himself upon his horse and rode madly off in all directions." - Stephen B. Leacock