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complement factor D (adipsin)
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| Identifiers | |
| Symbol | CFD |
| Alt. Symbols | DF, PFD |
| Entrez | 1675 |
| HUGO | 2771 |
| OMIM | 134350 |
| RefSeq | NM_001928 |
| UniProt | P00746 |
| Other data | |
| Locus | Chr. 19 p13.3 |
Factor D also known as complement factor D(CFD) or adipsin a protein which in humans is encoded by the CFD gene.[1] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.
Contents |
Function
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.[1]
Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.[2]
Clinical significance
The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.
References
- ^ a b "Entrez Gene: CFD". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1675.
- ^ Ronti T, Lupattelli G, Mannarino E (April 2006). "The endocrine function of adipose tissue: an update". Clin. Endocrinol. (Oxf) 64 (4): 355–65. doi:. PMID 16584505. Lay summary – medscape.com.
External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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