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| Fc fragment of IgG, low affinity IIa, receptor (CD32) | ||||||||||||||
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| PDB rendering based on 1fcg. | ||||||||||||||
| Available structures | ||||||||||||||
| 1fcg, 1h9v, 2fcb | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | FCGR2A; CD32; CD32A; CDw32; FCG2; FCGR2; FCGR2A1; FcGR; IGFR2; MGC23887; MGC30032 | |||||||||||||
| External IDs | OMIM: 146790 MGI: 95500 HomoloGene: 47936 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| More reference expression data | ||||||||||||||
| Orthologs | ||||||||||||||
| Species | Human | Mouse | ||||||||||||
| Entrez | 2212 | 14131 | ||||||||||||
| Ensembl | ENSG00000143226 | ENSMUSG00000059498 | ||||||||||||
| UniProt | P12318 | Q5D5I8 | ||||||||||||
| RefSeq | XM_001129584 (mRNA) | NM_010188 (mRNA) | ||||||||||||
| XP_001129584 (protein) | NP_034318 (protein) | |||||||||||||
| Location | Chr 1: 159.74 - 159.76 Mb |
Chr 1: 172.89 - 172.9 Mb |
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| PubMed search | [1] | [2] | ||||||||||||
Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[1][2]
Contents |
Interactions
FCGR2A has been shown to interact with PIK3R1[3][4] and Syk.[4][5]
See also
References
- ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. PMID 2139735.
- ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2212.
- ^ Chacko, G W; Brandt J T, Coggeshall K M, Anderson C L (May. 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. (UNITED STATES) 271 (18): 10775–81. ISSN 0021-9258. PMID 8631888.
- ^ a b Ibarrola, I; Vossebeld P J, Homburg C H, Thelen M, Roos D, Verhoeven A J (Jul. 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta (NETHERLANDS) 1357 (3): 348–58. ISSN 0006-3002. PMID 9268059.
- ^ Kim, M K; Pan X Q, Huang Z Y, Hunter S, Hwang P H, Indik Z K, Schreiber A D (Jan. 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. (UNITED STATES) 98 (1): 125–32. doi:. ISSN 1521-6616. PMID 11141335.
Further reading
- McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders.". Blood Rev. 16 (1): 3–5. doi:. PMID 11913983.
- Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.". J. Biol. Chem. 267 (22): 15692–700. PMID 1379234.
- Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics 30 (1): 5–12. doi:. PMID 2526077.
- Hessian PA, Highton J, Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis.". Clin. Exp. Immunol. 77 (1): 47–51. PMID 2527651.
- Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.". J. Exp. Med. 170 (4): 1369–85. doi:. PMID 2529342.
- Lanier LL, Cwirla S, Yu G, et al. (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid.". Science 246 (4937): 1611–3. doi:. PMID 2531919.
- Stuart SG, Trounstine ML, Vaux DJ, et al. (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).". J. Exp. Med. 166 (6): 1668–84. doi:. PMID 2824655.
- Hibbs ML, Bonadonna L, Scott BM, et al. (1988). "Molecular cloning of a human immunoglobulin G Fc receptor.". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. doi:. PMID 2965389.
- Huizinga TW, van der Schoot CE, Jost C, et al. (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils.". Nature 333 (6174): 667–9. doi:. PMID 2967437.
- Sammartino L, Webber LM, Hogarth PM, et al. (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1.". Immunogenetics 28 (5): 380–1. doi:. PMID 2971615.
- Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.". EMBO J. 7 (4): 1053–9. PMID 3402431.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides.". J. Biol. Chem. 271 (18): 10775–81. doi:. PMID 8631888.
- Salmon JE, Millard S, Schachter LA, et al. (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.". J. Clin. Invest. 97 (5): 1348–54. doi:. PMID 8636449.
- Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.
- Sármay G, Koncz G, Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway.". J. Biol. Chem. 271 (48): 30499–504. doi:. PMID 8940017.
- Ibarrola I, Vossebeld PJ, Homburg CH, et al. (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa.". Biochim. Biophys. Acta 1357 (3): 348–58. doi:. PMID 9268059.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:. PMID 9373149.
- De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood 91 (6): 2108–17. PMID 9490697.
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