Febrile non-hemolytic transfusion reaction is a type of transfusion reaction that is associated with fever but not directly with hemolysis.
It is abbreviated "FNHTR".[1]
The reaction can be mediated by cytokines.[2][3]
Acetaminophen and diphenhydramine have been used in treatment, and leukoreduction of future transfusions is sometimes performed.[4]
References
- ^ Heddle NM (November 1999). "Pathophysiology of febrile nonhemolytic transfusion reactions". Curr. Opin. Hematol. 6 (6): 420–6. PMID 10546797. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1065-6251&volume=6&issue=6&spage=420.
- ^ Addas-Carvalho M, Salles TS, Saad ST (June 2006). "The association of cytokine gene polymorphisms with febrile non-hemolytic transfusion reaction in multitransfused patients". Transfus Med 16 (3): 184–91. doi:. PMID 16764597. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0958-7578&date=2006&volume=16&issue=3&spage=184.
- ^ Yazer MH, Podlosky L, Clarke G, Nahirniak SM (January 2004). "The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC". Transfusion 44 (1): 10–5. PMID 14692961. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0041-1132&date=2004&volume=44&issue=1&spage=10.
- ^ "Complications of Transfusion: Transfusion Medicine: Merck Manual Professional". http://www.merck.com/mmpe/sec11/ch146/ch146e.html#sec11-ch146-ch146d-1093. Retrieved on 2009-02-09.
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