Proto-oncogene tyrosine-protein kinase Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2]
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[2]
Interactions
Feline sarcoma oncogene has been shown to interact with BCAR1[3] and BCR gene.[4][5]
References
- ^ Bowden DW, Akots G, Rothschild CB (Sep 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Res 19 (15): 4311. PMID 1870997.
- ^ a b "Entrez Gene: FES feline sarcoma oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242.
- ^ Jücker, M; McKenna K, da Silva A J, Rudd C E, Feldman R A (Jan. 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". J. Biol. Chem. (UNITED STATES) 272 (4): 2104–9. ISSN 0021-9258. PMID 8999909.
- ^ Lionberger, J M; Smithgall T E (Feb. 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Res. (UNITED STATES) 60 (4): 1097–103. ISSN 0008-5472. PMID 10706130.
- ^ Maru, Y; Peters K L, Afar D E, Shibuya M, Witte O N, Smithgall T E (Feb. 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. (UNITED STATES) 15 (2): 835–42. ISSN 0270-7306. PMID 7529874.
Further reading
- Smithgall TE, Rogers JA, Peters KL, et al. (1998). "The c-Fes family of protein-tyrosine kinases.". Critical reviews in oncogenesis 9 (1): 43–62. PMID 9754447.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
- Greer P (2002). "Closing in on the biological functions of Fps/Fes and Fer.". Nat. Rev. Mol. Cell Biol. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.
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1wqu: Solution structure of the human FES SH2 domain
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2dcr: Fully automated solution structure determination of the Fes SH2 domain
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