Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene.[1][2][3]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.[3]
References
- ^ Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N (Mar 1999). "Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain". Biochim Biophys Acta 1444 (1): 148-51. PMID 9931477.
- ^ Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, Vagts A, Foster J, Liang J, Brush J, Gu Q, Hillan K, Goddard A, Gurney AL (Nov 1999). "FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4". Cytokine 11 (10): 729-35. doi:10.1006/cyto.1999.0485. PMID 10525310.
- ^ a b "Entrez Gene: FGF19 fibroblast growth factor 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9965.
Further reading
- Ladher RK, Anakwe KU, Gurney AL, et al. (2000). "Identification of synergistic signals initiating inner ear development.". Science 290 (5498): 1965–7. doi:10.1126/science.290.5498.1965. PMID 11110663.
- Tomlinson E, Fu L, John L, et al. (2002). "Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.". Endocrinology 143 (5): 1741–7. doi:10.1210/en.143.5.1741. PMID 11956156.
- Nicholes K, Guillet S, Tomlinson E, et al. (2002). "A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice.". Am. J. Pathol. 160 (6): 2295–307. PMID 12057932.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Katoh M, Katoh M (2004). "Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human.". Int. J. Mol. Med. 12 (1): 45–50. PMID 12792807.
- Holt JA, Luo G, Billin AN, et al. (2003). "Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.". Genes Dev. 17 (13): 1581–91. doi:10.1101/gad.1083503. PMID 12815072.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Harmer NJ, Pellegrini L, Chirgadze D, et al. (2004). "The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.". Biochemistry 43 (3): 629–40. doi:10.1021/bi035320k. PMID 14730967.
- Fu L, John LM, Adams SH, et al. (2004). "Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.". Endocrinology 145 (6): 2594–603. doi:10.1210/en.2003-1671. PMID 14976145.
- Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Tamimi Y, Skarie JM, Footz T, et al. (2006). "FGF19 is a target for FOXC1 regulation in ciliary body-derived cells.". Hum. Mol. Genet. 15 (21): 3229–40. doi:10.1093/hmg/ddl400. PMID 17000708.
- Goetz R, Beenken A, Ibrahimi OA, et al. (2007). "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.". Mol. Cell. Biol. 27 (9): 3417–28. doi:10.1128/MCB.02249-06. PMID 17339340.
- Wu X, Ge H, Gupte J, et al. (2007). "Co-receptor requirements for fibroblast growth factor-19 signaling.". J. Biol. Chem. 282 (40): 29069–72. doi:10.1074/jbc.C700130200. PMID 17711860.
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1pwa: Crystal structure of Fibroblast Growth Factor 19
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2p23: Crystal structure of human FGF19
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