In nuclear strategy, first strike capability is a country's ability to defeat another nuclear power by destroying its arsenal to the point where the attacking country can survive the weakened retaliation.
First strike may also refer to:
- First Strike (Def Leppard album), an unreleased album recorded by Def Leppard in 1979, released in 1984
- "First Strike" (Stargate Atlantis), an episode of the TV series Stargate Atlantis
- Police Story 4: First Strike, AKA Jackie Chan's First Strike, a 1995 action movie
- Halo: First Strike, a 2003 novel written by Eric Nylund. It is based on the video game series
- First Strike Coins, the first coins struck from a new set of dies
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- First Strike (Documentary) a 1979 documentary film about nuclear war.
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