Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.[1]
Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM][2]
Interactions
FLT1 has been shown to interact with PLCG1[3] and Vascular endothelial growth factor B.[4][5]
See also
References
- ^ Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (May 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene 5 (4): 519–24. PMID 2158038.
- ^ "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321.
- ^ Cunningham, S A; Arrate M P, Brock T A, Waxham M N (Nov. 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. ISSN 0006-291X. PMID 9398617.
- ^ Olofsson, B; Korpelainen E, Pepper M S, Mandriota S J, Aase K, Kumar V, Gunji Y, Jeltsch M M, Shibuya M, Alitalo K, Eriksson U (Sep. 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11709–14. ISSN 0027-8424. PMID 9751730.
- ^ Makinen, T; Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (Jul. 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. (UNITED STATES) 274 (30): 21217–22. ISSN 0021-9258. PMID 10409677.
Further reading
- Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
- Sato Y, Kanno S, Oda N, et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.". Ann. N. Y. Acad. Sci. 902: 201–5; discussion 205–7. PMID 10865839.
- Boyd AW, Lackmann M (2002). "Signals from Eph and ephrin proteins: a developmental tool kit.". Sci. STKE 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
- Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders.". Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719.
- Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia.". Pediatr. Res. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
- Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis.". Angiogenesis 9 (4): 225–30; discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
- Widmer M, Villar J, Benigni A, et al. (2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review.". Obstetrics and gynecology 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
- López-Novoa JM (2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia.". Nephrol. Dial. Transplant. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.
- Poesen K, Lambrechts D et al. (2008). "Novel Role for Vascular Endothelial Growth Factor (VEGF)Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration". J. Neurosci. 28 (42): 10451–9. PMID 18923022.
- Joukov V, Kaipainen A, Jeltsch M, et al. (1997). "Vascular endothelial growth factors VEGF-B and VEGF-C.". J. Cell. Physiol. 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211:: AID-JCP23>3.0.CO;2-H. PMID 9365524.
- Rosandra N. Kaplan, Rebecca D. Riba, et al. (2005). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature 438 (7069): 820–7. doi:doi:10.1038/nature04186. PMID 16341007.
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1flt: VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
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1qsv: THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES
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1qsz: THE VEGF-BINDING DOMAIN OF FLT-1 (MINIMIZED MEAN)
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1qty: VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
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1rv6: Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
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