Fluorometholone

Brand names: Eflone™, Flarex®, Fluor-Op®, FML Forte S.O.P.®, FML Forte®, FML®

Chemical formula:

Last updated: 7/1/2002

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A topical anti-inflammatory glucocorticoid.

Fluorometholone
Systematic (IUPAC) name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Identifiers
CAS number	426-13-1
ATC code	C05AA06 D07AB06, D07XB04, D10AA01, S01BA07, S01CB05
PubChem	9878
DrugBank	APRD00980
Chemical data
Formula	C22H29FO4
Mol. mass	376.462 g/mol
Synonyms	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status
Routes	?

Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon).

Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

External links

• Drugs.com
• flarex
• Alcon official page

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v • d • e Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor (A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS) Mineralocorticoids (3-one, 4-ene, no FG at 16) Pregnenedione: ALDOSTERONE · 11-DEOXYCORTICOSTERONE · HALOGENATED AT 9: Fludrocortisone Glucocorticoids (3-one, 4-ene, 11-FG, 17-hydroxy) Pregnene CORTISONE Pregnenedione (+20-one) HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) · Budesonide · Ciclesonide · Deflazacort · Medrysone · Tixocortol · HALOGENATED AT 6: Cloprednol · HALOGENATED, WITH FG AT 16: Halcinonide Pregnadiene (+1-ene) Rimexolone · HALOGENATED, WITH FG AT 16: Flunisolide · Triamcinolone · Amcinonide · Fluocinolone acetonide (Fluocinonide) Pregnadienediol (+21-hydroxy) Prednisone (Meprednisone) · HALOGENATED AT 9: Fluorometholone · HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) · Desoximetasone Pregnadienetriol (+11-hydroxy) Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) · Desonide · HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) · HALOGENATED, WITH FG AT 16: Dexamethasone# · Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) · Beclometasone · Paramethasone  · Alclometasone · Fluclorolone · Flumetasone · Fluprednidene Pregnatriene (+2-ene) Cortivazol Androstene HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate) Other/ungrouped HALOGENATED: Loteprednol · HALOGENATED, WITH FG AT 16: Fludroxycortide · Formocortal · Mometasone furoate Aldosterone antagonists Spironolactone · Eplerenone · Potassium canrenoate · Canrenone Synthesis Trilostane · Carbenoxolone · Aminoglutethimide · Metyrapone #WHO-EM. †Undergoing clinical trials, not FDA approved. ‡Withdrawn from market. §Development halted.

v • d • e Vasoprotectives (C05) Antihemorrhoidals for topical use corticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) other (Tribenoside) Antivaricose therapy heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) other (Calcium dobesilate) Capillary stabilising agents bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

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