For the progressive rock/metal band, see Frameshift (band).
A directed change in translational reading frames that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses; retrotransposons; and bacterial insertion elements but also in some cellular genes.
Notably the p19 tumor suppressor gene in humans encodes a frameshift.
See also
External links
- MeSH Frameshifting,+Ribosomal
- Wise2 - aligns a protein against a DNA sequence allowing frameshifts and introns
- FastY - compare a DNA sequence to a protein sequence database, allowing gaps and frameshifts
- Path - tool that compares two frameshift proteins (back-translation principle)
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