Share on Facebook Share on Twitter Email
Answers.com

GABA transaminase inhibitor

 
Wikipedia: GABA transaminase inhibitor
Home > Library > Miscellaneous > Wikipedia

A GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase.

Examples include vigabatrin[1] and ethanolamine-O-sulfate (EOS).

Certain members of this class are used as anticonvulsants.

References

  1. ^ Wang QP, Jammoul F, Duboc A, et al (April 2008). "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina". Eur. J. Neurosci. 27 (8): 2177–87. doi:10.1111/j.1460-9568.2008.06175.x. PMID 18412635. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2008&volume=27&issue=8&spage=2177. 
v • d • e
GABAergics
Receptor
Ligands
Agonists: Main Site: Gaboxadol • Ibotenic Acid • Isoguvacine • Isonipecotic Acid • Muscimol (Amanita Muscaria) • Progabide • SL 75102 • Thiomuscimol; Positive Allosteric Modulators: Barbiturates • Benzodiazepines • Carbamates • Chlormezanone • Clomethiazole • Etazolate • Ethanol (Alcohol) • Etomidate • Kavalactones (Kava Kava) • Loreclezole • Neuroactive Steroids • Nonbenzodiazepines • Phenols • Piperidinediones • Propanidid • Quinazolinones • ROD-188 • Skullcap • Stiripentol • Valerenic Acid (Valerian)
* See here for a full list of GABAA positive allosteric modulators.
Antagonists: Main Site: Bicuculline • Gabazine; Negative Allosteric Modulators: α5IA • Bilobalide • Cicutoxin • DMCM • Flumazenil • Furosemide • L-655,708 • Oenanthotoxin • Penicillin • Pentylenetetrazol • Picrotoxin • PWZ-029 • Ro15-4513 • Sarmazenil • Suritozole • Thujone (Absinthe)
Agonists: Main Site: 1,4-Butanediol • Baclofen • GBL • GHB • GHV • GVL • Phenibut • Progabide; Positive Allosteric Modulators: BHF-177 • BHFF • BSPP • CGP-7930 • GS-39783
Antagonists: Main Site: Phaclofen • Saclofen • SCH-50911
Agonists: Main Site: CACA • CAMP • GABOB • N(4)-chloroacetylcytosine arabinoside
Antagonists: Main Site: Bilobalide • TPMPA
Reuptake
Inhibitors
GAT Inhibitors
CI-966 • Deramciclane • EF-1502 • Gabaculine • Guvacine • Nipecotic acid • NNC 05-2090 • SKF-89976A • SNAP-5114 • Tiagabine
TRPC6 Activators
VGAT Inhibitors
.....
Enzyme
Inhibitors
GAD Inhibitors
GABA-T Inhibitors
3-Hydrazinopropionic Acid • Aminooxyacetic Acid • Gabaculine • Gabapentin • Isoniazid • Phenelzine • Phenylethylidenehydrazine • Pregabalin • Valnoctamide • Valproic acid • Valpromide • Vigabatrin
Others
Others
v • d • e
Anticonvulsants (N03)
GABAA receptor agonist
Other GABA agents
Carbonic anhydrase inhibitor
Channel blockers
Primarily sodium
Primarily calcium
Unknown/ungrouped
Indirect GABA agents
Unknown/multiple/
unsorted
v • d • e
Pharmacology: enzyme inhibition
Class
Substrate
Hydrolase (EC 3)
Lyase (EC 4)

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)

Search unanswered questions...

Enter a question here...
Search: All sources Community Q&A Reference topics

 
 

 

Copyrights:

Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "GABA transaminase inhibitor".  Read more