Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.[1][2]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.[2]
See also
References
Further reading
- Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750–7. doi:10.1074/jbc.272.21.13750. PMID 9153229.
- Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716.
- Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2-3): 307–12. PMID 10542332.
- Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
- Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor.". Int. J. Dev. Neurosci. 20 (3-5): 237–46. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859.
- Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gamel-Didelon K, Kunz L, Fohr KJ, et al. (2003). "Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells.". J. Biol. Chem. 278 (22): 20192–5. doi:10.1074/jbc.M301729200. PMID 12660236.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Ion channel, receptor: ligand-gated ion channels |
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GABAA ( α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ ( ρ1, ρ2, ρ3)
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Zinc
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Ligand-gated only
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Voltage- and ligand-gated
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