Ganirelix

Brand names: Antagon™

Chemical formula:

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Ganirelix
Systematic (IUPAC) name
(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
Identifiers
CAS number	123246-29-7 129311-55-3 (diacetate)
ATC code	H01CC01
PubChem	25081094
Chemical data
Formula	C80H113ClN18O13
Mol. mass	1570.4 g/mol
Pharmacokinetic data
Bioavailability	91.1%
Protein binding	81.9%
Metabolism	?
Half life	12.8 hours
Excretion	Faecal / Renal (approx. 75%/22%)
Therapeutic considerations
Pregnancy cat.	X(US)
Legal status	℞-only(US)
Routes	Subcutaneous injection

Ganirelix acetate (or diacetate) is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. It is administered as a daily subcutaneous injection.

Ganirelix is marketed by Organon International as Antagon.

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) – human endogenous in SMALL CAPS   Progestogens/progestins: (receptor) Agonist PROGESTERONE · Dienogest · Desogestrel · Drospirenone · Dydrogesterone · Ethisterone · Etonogestrel · Ethynodiol diacetate · Gestodene · Gestonorone · Levonorgestrel# · Lynestrenol · Medroxyprogesterone/Medroxyprogesterone 17-acetate# · Megestrol · Melengestrol · Norelgestromin · Norethisterone# · Norethynodrel · Norgestimate · Norgestrel · Norgestrienone · Tibolone SPRM Asoprisnil · CDB-4124 Antiprogestogen Mifepristone   Androgens: (receptor) Agonist TESTOSTERONE# · Androstanolone · Fluoxymesterone · Mesterolone · Methyltestosterone · see also Anabolic steroids SARM AC-262,356 · Andarine · BMS-564,929 · LGD-2226 · LGD-3303 · Ostarine · S-23 · S-40503 5α-reductase inhibitors Dutasteride · Finasteride CYP17A1 inhibitors Abiraterone Antiandrogen Bicalutamide · Cyproterone · Dienogest · Flutamide · MDV3100 · Nilutamide · Spironolactone   Estrogens: (receptor) Agonist ESTRADIOL · ESTRIOL · ESTRONE · Ethinylestradiol#/Mestranol · Polyestradiol phosphate · Estradiol 17 beta-cypionate#; nonsteroidal (Chlorotrianisene · Dienestrol · Fosfestrol · Diethylstilbestrol · Zeranol) SERM Afimoxifene · Arzoxifene · Bazedoxifene · Cyclofenil · Lasofoxifene · Ormeloxifene · Raloxifene · Tamoxifen · Toremifene Aromatase inhibitors nonselective: Aminoglutethimide · Testolactone selective: Anastrozole · Atamestane · Exemestane · Fadrozole · Formestane · Letrozole · Vorozole Antiestrogen Clomifene# · Fulvestrant · Mepitiostane · Nafoxidine   Gonadotropins: (FSHR/LHCGR) Agonist Menotropin · Urofollitropin Antigonadotropin Danazol · Gestrinone   GnRH: (receptor) Agonist Buserelin · Goserelin · Histrelin · Leuprorelin · Nafarelin · Triptorelin · Deslorelin Antagonist Abarelix · Cetrorelix · Degarelix · Ganirelix #WHO-EM. †Undergoing clinical trials, not FDA approved. ‡Withdrawn from market. §Development halted.

v • d • e Hypothalamic-pituitary hormones and analogues (H01) Hypothalamic GNRH agonists: Gonadorelin · Nafarelin · Histrelin antagonists: Ganirelix · Cetrorelix Somatostatin Octreotide · Lanreotide Anterior pituitary ACTH agonists: Corticotropin · Tetracosactide · Cosyntropin TSH agonist: Thyrotropin GH agonists: Somatrem · Sermorelin · IGF-1 (Mecasermin/Mecasermin rinfabate) antagonist: Pegvisomant Posterior pituitary Vasopressin agonists: Desmopressin · Felypressin · Lypressin · Terlipressin · Ornipressin · Argipressin antagonists: Conivaptan · Demeclocycline · Lixivaptan · Mozavaptan · Nelivaptan · Relcovaptan · Satavaptan · Tolvaptan Oxytocin agonists: Demoxytocin · Carbetocin antagonists: Atosiban

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)