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Gatifloxacin

 
Drug Info: Gatifloxacin

Brand names: Tequin®Zymar™

Chemical formula:



Gatifloxacin Ophthalmic drops, solution

What is this medicine?

GATIFLOXACIN (ga ti FLOKS a sin) is an quinolone antibiotic. It is used to treat bacterial eye infections.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•contact lens wearer
•an unusual or allergic reaction to gatifloxacin or other fluoroquinolone antibiotics, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is only for use in the eye. Follow the directions on the prescription label. Wash hands before and after each use. Try not to touch the tip of the dropper to anything, even your eye or fingertips. Tilt your head back slightly and pull your lower eyelid down with your finger to form a pouch. Squeeze the prescribed number of drops into the pouch. Close the eye gently. Your vision may blur for a few minutes. Use your doses at regular intervals. Do not take your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 1 year for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Interactions are not expected. Do not use any other eye products without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not improve in 2 to 3 days.

If your eyes are more sensitive to light, wear sunglasses.

Do not wear contact lenses while you have any signs or symptoms of an eye infection. Ask your doctor or health care professional when you can start wearing your lenses again.

Stop using this medicine immediately if you notice signs of an allergic reaction.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional immediately:
•burning, stinging, or itching of the eyes or eyelids
•redness, blistering, swelling, or pain
•swollen eyelids

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•change in taste
•dry eyes
•headache
•problems with vision
•red eyes
•tearing

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from freezing. Throw away any unused medicine after the expiration date.

Last updated: 12/15/2004 4:17:00 PM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: gatifloxacin
Top

A fluoroquinolone antibiotic with activity against anaerobic bacteria.

Wikipedia: Gatifloxacin
Top
Gatifloxacin
Systematic (IUPAC) name
1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid
Identifiers
CAS number 112811-59-3
ATC code J01MA16 S01AX21
PubChem 5379
DrugBank APRD00996
Chemical data
Formula C19H22FN3O4 
Mol. mass 375.394 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 20%
Metabolism  ?
Half life 7 to 14 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Rx only

Routes Oral (discontinued),
Intravenous (discontinued)
ophthalmic
 Yes check.svgY(what is this?)  (verify)

Gatifloxacin sold under the brand names Gatiflo, Tequin and Zymar, is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Bristol-Myers Squibb introduced Gatifloxacin in 1999 under the proprietary name Tequin for the treatment of respiratory tract infections, having licensed the medication from Kyorin Pharmaceutical Company of Japan. Allergan produces an eye-drop formulation called Zymar. In many countries, gatifloxacin is also available as tablets and in various aqueous solutions for intravenous therapy.

Contents

Side-effects and removal from the market

A Canadian study published in the New England Journal of Medicine in March 2006 claims Tequin can have "life threatening" side effects including serious diabetes.[1] An editorial by Dr. Jerry Gurwitz in the same issue called for the Food and Drug Administration (FDA) to consider giving Tequin a black box warning.[2] This editorial followed distribution of a letter dated February 15 by Bristol-Myers Squibb to health care providers indicating action taken with the FDA to strengthen warnings for the medication.[3] Subsequently it was reported on May 1, 2006 that Bristol-Myers Squibb would stop manufacture of Tequin, end sales of the drug after existing stockpiles were exhausted, and return all rights to Kyorin.[4]

Other serious side effects reported with gatifloxacin include hallucinations or liver damage.[5][6]

Contraindications

Diabetes[7]

Availability

Gatifloxacin is currently available only in the US and Canada as an ophthalmic solution.

In India it is sold in tablet as well as in eye drop formulations.

See also

References

  1. ^ Park-Wyllie, Laura Y.; David N. Juurlink, Alexander Kopp, Baiju R. Shah, Therese A. Stukel, Carmine Stumpo, Linda Dresser, Donald E. Low, Muhammad M. Mamdani (March 2006). "Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults". The New England Journal of Medicine 354 (13): 1352–1361. doi:10.1056/NEJMoa055191. PMID 16510739. http://content.nejm.org/cgi/content/abstract/354/13/1352. Retrieved 2006-05-01.  Note: publication date 30 March; available on-line 1 March
  2. ^ Gurwitz, Jerry H. (March 2006). "Serious Adverse Drug Effects — Seeing the Trees through the Forest". The New England Journal of Medicine 354 (13): 1413–1415. doi:10.1056/NEJMe068051. PMID 16510740. http://content.nejm.org/cgi/content/extract/354/13/1413. Retrieved 2006-05-01. 
  3. ^ Lewis-Hall, Freda (February 15, 2006). "Dear Healthcare Provider:" (PDF). Bristol-Myers Squibb. http://www.fda.gov/medwatch/safety/2006/tequin_DHCP.pdf. Retrieved May 1, 2006. 
  4. ^ Schmid, Randolph E. (May 1, 2006). "Drug Company Taking Tequin Off Market". Associated Press. http://www.sfgate.com/cgi-bin/article.cgi?file=/news/archive/2006/05/01/national/w120748D88.DTL&type=health. Retrieved 2006-05-01. 
  5. ^ Adams M, Tavakoli H (2006). "Gatifloxacin-induced hallucinations in a 19-year-old man". Psychosomatics 47 (4): 360. doi:10.1176/appi.psy.47.4.360. PMID 16844899. http://psy.psychiatryonline.org/cgi/content/full/47/4/360. 
  6. ^ Coleman CI, Spencer JV, Chung JO, Reddy P (2002). "Possible gatifloxacin-induced fulminant hepatic failure". Ann Pharmacother 36 (7-8): 1162–7. doi:10.1345/aph.1A414. PMID 12086547. 
  7. ^ Peggy Peck (2 May 2006). "Bristol-Myers Squibb Hangs No Sale Sign on Tequin". Med Page Today. http://www.medpagetoday.com/PrimaryCare/PreventiveCare/3212. Retrieved 24 February 2009. 

 
 
Learn More
Gatifloxacin eye solution
Gatifloxacin oral suspension
Fluoroquinolones

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Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Gatifloxacin" Read more