Gems or GEMS can refer to:
- gemstones, or
- GEMS, "General Economic & Market Simulator", an advanced ESG (Economic Scenario Generator) authored by DFA Capital Management Inc., which is used in stochastic financial projections.
- Gems (album), the 1988 album by Aerosmith.
- Gems, a 1994 studio album by Patti LaBelle
- Gems TV, a shopping channel specializing in Gemstones.
- A package format of Ruby library under RubyGems
- GEMS, Global Election Management System, the software that runs on Premier Election Solutions (formerly Diebold Election Systems) DRE voting machines
- GEMS, a software development tool called Generic Eclipse Modeling System
- Sonic Gems Collection, a video game.
- GEMs, in Biology, Glycosphingolipid-enriched microdomains, also known as Lipid Rafts.
- Gaston County EMS (GEMS), Gaston Emergency Medical Services, Ambulance Service for Gaston County, NC
- An abbreviation of Gosforth East Middle School in Gosforth, Newcastle upon Tyne, England
- GEMS (Gravity and Extreme Magnetism SMEX) satellite
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