Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[1][2][3]
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][3]
See also
References
- ^ Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics 50 (3): 341-5. doi:10.1006/geno.1998.5324. PMID 9676428.
- ^ Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res 35 (1-2): 211-9. PMID 8717357.
- ^ a b "Entrez Gene: GLRB glycine receptor, beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2743.
Further reading
- Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit.". Neuron 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736.
- Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys.". Nephron 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998.
- Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB).". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors.". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
- Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation.". Recept. Channels 9 (6): 353–61. PMID 14698963.
- Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors.". Neuron 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848.
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1t3e: Structural basis of dynamic glycine receptor clustering
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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GABAA ( α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ ( ρ1, ρ2, ρ3)
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Ligand-gated only
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Voltage- and ligand-gated
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