Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis. It should not be confused with "glucose isomerase", which is actually a common name for D-xylose isomerase (EC 5.3.1.5) in the high-fructose corn syrup industry.
The human variant of this enzyme is encoded by the GPI gene.
In glycolysis
Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Reaction R00771 at KEGG Pathway Database.
As a glucose isomerase
Other functions
There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.
Pathology
A deficiency of phosphoglucose isomerase is responsible for 4% of the hemolytic anemias due to glycolytic enzyme deficiencies.
External links
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