| integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | |
|---|---|
| Identifiers | |
| Symbol | ITGA2B |
| Alt. symbols | GP2B |
| Entrez | 3674 |
| HUGO | 6138 |
| OMIM | 607759 |
| RefSeq | NM_000419 |
| UniProt | P08514 |
| Other data | |
| Locus | Chr. 17 q21.32 |
| integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | |
|---|---|
| Identifiers | |
| Symbol | ITGB3 |
| Alt. symbols | GP3A |
| Entrez | 3690 |
| HUGO | 6156 |
| OMIM | 173470 |
| RefSeq | NM_000212 |
| UniProt | P05106 |
| Other data | |
| Locus | Chr. 17 q21.32 |
In medicine, glycoprotein IIb/IIIa, also gpIIb/IIIa, is an integrin found on platelets. It is a receptor for fibrinogen and aids in platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.[1][2] Platelet activation by ADP leads to a conformational change in in platelet gpIIb/IIIa receptors that induces binding to fibrinogen.
Contents |
Pathology
Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia.[3]
Autoantibodies against IIb/IIIa can be produced in immune thrombocytopenic purpura.[4]
Medicine
Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.
See also
References
- ^ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429.
- ^ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720.
- ^ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:. PMID 12163005.
- ^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:. PMID 18096470. http://linkinghub.elsevier.com/retrieve/pii/S0037-1963(07)00159-X.
External links
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