| Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
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| PDB rendering based on 1agr. |
| Available structures |
| 1agr, 1as0, 1as2, 1as3, 1bh2, 1bof, 1cip, 1gdd, 1gfi, 1gg2, 1gia, 1gil, 1git, 1gp2, 1kjy, 1svk, 1svs, 1y3a, 2g83, 2gtp, 2hlb, 2ihb, 2ik8, 2ode |
| Identifiers |
| Symbols |
GNAI1; Gi |
| External IDs |
OMIM: 139310 MGI: 95771 HomoloGene: 74417 |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
2770 |
14677 |
| Ensembl |
ENSG00000127955 |
ENSMUSG00000057614 |
| UniProt |
P63096 |
n/a |
| RefSeq |
NM_002069 (mRNA) |
NM_010305 (mRNA) |
| NP_002060 (protein) |
NP_034435 (protein) |
| Location |
Chr 7:
79.6 - 79.69 Mb |
Chr 5:
17.78 - 17.87 Mb |
| PubMed search |
[1] |
[2] |
Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[1][2]
Interactions
GNAI1 has been shown to interact with GPR143,[3] RGS14,[4][5] RIC8A,[6] S1PR1,[7] RGS12[4] and RGS19.[8][9]
References
- ^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proc Natl Acad Sci U S A 84 (15): 5115–9. PMID 3110783.
- ^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2770.
- ^ Schiaffino, M V; d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi M T, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep. 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat. Genet. (UNITED STATES) 23 (1): 108–12. doi:10.1038/12715. ISSN 1061-4036. PMID 10471510.
- ^ a b Kimple, R J; De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P (Aug. 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. (United States) 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.
- ^ Kimple, Randall J; Kimple Michelle E, Betts Laurie, Sondek John, Siderovski David P (Apr. 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature (England) 416 (6883): 878–81. doi:10.1038/416878a. ISSN 0028-0836. PMID 11976690.
- ^ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (Mar. 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
- ^ Lee, M J; Evans M, Hla T (May. 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. ISSN 0021-9258. PMID 8626678.
- ^ Woulfe, D S; Stadel J M (Jun. 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. ISSN 0021-9258. PMID 10364213.
- ^ De Vries, L; Elenko E, Hubler L, Jones T L, Farquhar M G (Dec. 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. ISSN 0027-8424. PMID 8986788.
Further reading
- Sidhu A, Niznik HB (2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins.". Int. J. Dev. Neurosci. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID 10978845.
- Brown EJ, Frazier WA (2001). "Integrin-associated protein (CD47) and its ligands.". Trends Cell Biol. 11 (3): 130–5. doi:10.1016/S0962-8924(00)01906-1. PMID 11306274.
- Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
- Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. doi:10.1073/pnas.88.9.3907. PMID 1902575.
- Gennity JM, Siess W (1991). "Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.". Biochem. J. 279 ( Pt 3): 643–50. PMID 1953657.
- Itoh H, Toyama R, Kozasa T, et al. (1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.". J. Biol. Chem. 263 (14): 6656–64. PMID 2834384.
- Bloch DB, Bloch KD, Iannuzzi M, et al. (1988). "The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.". Am. J. Hum. Genet. 42 (6): 884–8. PMID 3130752.
- Nagata K, Katada T, Tohkin M, et al. (1988). "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.". FEBS Lett. 237 (1-2): 113–7. doi:10.1016/0014-5793(88)80182-0. PMID 3139448.
- Kagimoto S, Yamada Y, Kubota A, et al. (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.". Biochem. Biophys. Res. Commun. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078.
- Nitta K, Uchida K, Kawashima A, et al. (1994). "Identification of GTP-binding proteins in human glomeruli.". Nippon Jinzo Gakkai shi 36 (1): 9–12. PMID 8107314.
- Law SF, Zaina S, Sweet R, et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.". Mol. Pharmacol. 45 (4): 587–90. PMID 8183236.
- Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.". Endocrinology 132 (6): 2484–90. doi:10.1210/en.132.6.2484. PMID 8504751.
- Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMID 8552586.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.
- De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMID 8986788.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
- Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216–20. doi:10.1073/pnas.94.14.7216. PMID 9207071.
- Shuey DJ, Betty M, Jones PG, et al. (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.". J. Neurochem. 70 (5): 1964–72. PMID 9572280.
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PDB Gallery |
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1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
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1as0: GTP-GAMMA-S BOUND G42V GIA1
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1as2: GDP+PI BOUND G42V GIA1
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1as3: GDP BOUND G42V GIA1
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1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
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1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
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1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
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1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
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1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
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1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
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1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
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1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
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1git: STRUCTURE OF GTP-BINDING PROTEIN
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1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
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1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14
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1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP
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1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.
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1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
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2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
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2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
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2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity
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2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3
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2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
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2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3
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