GNAL

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Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Identifiers
Symbols	GNAL;
External IDs	OMIM: 139312 MGI: 95774 HomoloGene: 68222
Gene ontology Molecular function • nucleotide binding • GTPase activity • signal transducer activity • GTP binding Biological process • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2774	14680
Ensembl	ENSG00000141404	ENSMUSG00000024524
UniProt	P38405	Q3TY78
RefSeq	NM_002071 (mRNA)	NM_010307 (mRNA)
	NP_002062 (protein)	NP_034437 (protein)
Location	Chr 18: 11.68 - 11.87 Mb	Chr 18: 67.21 - 67.35 Mb
PubMed search	[1]	[2]

Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.^[1][2]

References

1. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet 1 (2): 85-91. doi:10.1038/ng0592-85. PMID 1302014. 
2. ^ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2774. 

Further reading

• Zigman JM, Westermark GT, LaMendola J, et al. (1994). "Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.". Endocrinology 133 (6): 2508–14. doi:10.1210/en.133.6.2508. PMID 8243272. 
• Astesano A, Regnauld K, Ferrand N, et al. (1999). "Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells.". J. Histochem. Cytochem. 47 (3): 289–302. PMID 10026232. 
• Vuoristo JT, Berrettini WH, Overhauser J, et al. (2001). "Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia.". Mol. Psychiatry 5 (5): 495–501. doi:10.1038/sj.mp.4000758. PMID 11032382. 
• Zill P, Engel R, Baghai TC, et al. (2002). "Analysis of polymorphisms in the olfactory G-protein Golf in major depression.". Psychiatr. Genet. 12 (1): 17–22. doi:10.1097/00041444-200203000-00002. PMID 11901355. 
• Régnauld K, Nguyen QD, Vakaet L, et al. (2002). "G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells.". Oncogene 21 (25): 4020–31. doi:10.1038/sj.onc.1205498. PMID 12037684. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
• Zill P, Malitas PN, Bondy B, et al. (2004). "Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients.". Psychiatr. Genet. 13 (2): 65–9. doi:10.1097/01.ypg.0000057881.80011.45. PMID 12782961. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Corradi JP, Ravyn V, Robbins AK, et al. (2005). "Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.". Mol. Psychiatry 10 (11): 1017–25. doi:10.1038/sj.mp.4001713. PMID 16044173. 
• Ravyn V, Bostwick JR (2006). "Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor.". J. Recept. Signal Transduct. Res. 26 (4): 241–58. doi:10.1080/10799890600710592. PMID 16818375. 

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