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A goiter-producing agent. See also goitrogen-induced goiter.


 
 
WordNet: goitrogen
Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: any substance (such as thiouracil) that induces the formation of a goiter


 
Wikipedia: Goitrogen

Goitrogens are substances that suppress the function of the thyroid gland by interfering with iodine uptake which can, as a result, cause an enlargement of the thyroid.

Goitrogenic drugs

Chemicals that have been shown to have goitrogenic effects include:

Goitrogenic foods

Certain foods have been identified as goitrogenic. These foods include:

Foods stimulating thyroid tissue

Some foods and drinks have an opposite effect on the thyroid gland--that is, they stimulate thyroid function rather than suppressing it; examples being caffeine (coffee, tea, cola, and chocolate) and also avocado, coconut,[4] and saturated fat.[5]. Indeed some studies on rats suggest that excess caffiene in conjunction with a lack of iodine may promote the formation of thyroid cancers.[6]

Footnotes

  1. ^ Takizawa T, Imai T, Ueda M, Onodera H, Hirose M (2006). "Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds". Cancer Sci. 97 (1): 25–31. DOI:10.1111/j.1349-7006.2005.00132.x. PMID 16367917. 
  2. ^ Vanderpas J (2006). "Nutritional epidemiology and thyroid hormone metabolism". Annu. Rev. Nutr. 26: 293–322. DOI:10.1146/annurev.nutr.26.010506.103810. PMID 16704348. 
  3. ^ Akindahunsi AA, Grissom FE, Adewusi SR, Afolabi OA, Torimiro SE, Oke OL (1998). "Parameters of thyroid function in the endemic goitre of Akungba and Oke-Agbe villages of Akoko area of southwestern Nigeria". African journal of medicine and medical sciences 27 (3-4): 239–42. PMID 10497657. 
  4. ^ Siddhanti SR, King MW, Tove SB (1990). "Influence of dietary fat on factors in serum that regulate thyroid cell metabolism" (PDF). J. Nutr. 120 (11): 1297–304. PMID 2172489. 
    Thyroid hyperplasia has been demonstrated in mice:
    • (2001) "Toxicology and carcinogenesis studies of coconut oil acid diethanolamine condensate
    (CAS No. 68603-42-9) in F344/N rats and B6C3F1 mice (dermal studies)". National Toxicology Program technical report series 479: 5–226. PMID 12571684. 
  5. ^ Denice Moffat. Bad Foods for Thyroid. Retrieved on 2007-10-12.
  6. ^ Son HY, Nishikawa A, Kanki K, et al (2003). "Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine". Cancer Sci. 94 (4): 334–7. PMID 12824900. 

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See also


 
 

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Copyrights:

Veterinary Dictionary. The Veterinary Dictionary. Copyright © 2007 by Elsevier. All rights reserved.  Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Goitrogen" Read more

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