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Colony stimulating factor 3 receptor (granulocyte)
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| PDB rendering based on 2d9q. | ||||||||||||||
| Available structures: 2d9q | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | CSF3R; CD114; GCSFR | |||||||||||||
| External IDs | OMIM: 138971 MGI: 1339755 HomoloGene: 601 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1441 | 12986 | ||||||||||||
| Ensembl | ENSG00000119535 | n/a | ||||||||||||
| Uniprot | Q99062 | n/a | ||||||||||||
| Refseq | NM_000760 (mRNA) NP_000751 (protein) |
NM_007782 (mRNA) NP_031808 (protein) |
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| Location | Chr 1: 36.7 - 36.72 Mb | n/a | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114), is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).[1] The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.
Th G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Mutations in the intracellular part of this receptor are associated with certain types of leukemia.
GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.
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Isoforms
The class IV isoform defective for both internalization and differentiation signaling.
Interactions
Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2,[2] HCK[3] and SHC1.[2]
References
- ^ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1441.
- ^ a b Ward, A C; Monkhouse J L, Hamilton J A, Csar X F (Nov. 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta (NETHERLANDS) 1448 (1): 70-6. ISSN 0006-3002. PMID 9824671.
- ^ Ward, A C; Monkhouse J L, Csar X F, Touw I P, Bello P A (Oct. 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. (UNITED STATES) 251 (1): 117-23. doi:. ISSN 0006-291X. PMID 9790917.
See also
Further reading
- Tsuji K, Ebihara Y (2002). "Expression of G-CSF receptor on myeloid progenitors.". Leuk. Lymphoma 42 (6): 1351–7. PMID 11911419.
- Kimura A, Sultana TA (2005). "Granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukemia.". Leuk. Lymphoma 45 (10): 1995–2000. doi:. PMID 15370243.
- Tweardy DJ, Anderson K, Cannizzaro LA, et al. (1992). "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34.". Blood 79 (5): 1148–54. PMID 1371413.
- Seto Y, Fukunaga R, Nagata S (1992). "Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor.". J. Immunol. 148 (1): 259–66. PMID 1530796.
- Fukunaga R, Seto Y, Mizushima S, Nagata S (1991). "Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8702–6. doi:. PMID 1701053.
- Fukunaga R, Ishizaka-Ikeda E, Pan CX, et al. (1991). "Functional domains of the granulocyte colony-stimulating factor receptor.". Embo J. 10 (10): 2855–65. PMID 1717255.
- Inazawa J, Fukunaga R, Seto Y, et al. (1991). "Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3.". Genomics 10 (4): 1075–8. doi:. PMID 1833306.
- Larsen A, Davis T, Curtis BM, et al. (1991). "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.". J. Exp. Med. 172 (6): 1559–70. doi:. PMID 2147944.
- Uzumaki H, Okabe T, Sasaki N, et al. (1990). "Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9323–6. doi:. PMID 2480598.
- Nicholson SE, Oates AC, Harpur AG, et al. (1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 2985–8. doi:. PMID 7512720.
- Dong F, Hoefsloot LH, Schelen AM, et al. (1994). "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.". Proc. Natl. Acad. Sci. U.S.A. 91 (10): 4480–4. doi:. PMID 7514305.
- Dong F, Brynes RK, Tidow N, et al. (1995). "Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia.". N. Engl. J. Med. 333 (8): 487–93. doi:. PMID 7542747.
- Shimoda K, Okamura S, Harada N, et al. (1993). "Identification of a functional receptor for granulocyte colony-stimulating factor on platelets.". J. Clin. Invest. 91 (4): 1310–3. doi:. PMID 7682568.
- Zhao Y, Wagner F, Frank SJ, Kraft AS (1995). "The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.". J. Biol. Chem. 270 (23): 13814–8. doi:. PMID 7775438.
- Corey SJ, Burkhardt AL, Bolen JB, et al. (1994). "Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 4683–7. doi:. PMID 8197119.
- Haniu M, Horan T, Arakawa T, et al. (1996). "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.". Arch. Biochem. Biophys. 324 (2): 344–56. doi:. PMID 8554326.
- Horan T, Wen J, Narhi L, et al. (1996). "Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes.". Biochemistry 35 (15): 4886–96. doi:. PMID 8664280.
- McCracken S, Layton JE, Shorter SC, et al. (1996). "Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta.". J. Endocrinol. 149 (2): 249–58. doi:. PMID 8708536.
- Haniu M, Horan T, Arakawa T, et al. (1996). "Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.". Biochemistry 35 (40): 13040–6. doi:. PMID 8855939.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:. PMID 8889548.
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