Granulocytosis

Also from Answers.com... Bladder Problems Find out the different types, and ways to overcome this common problem.

(medicine) An increase in the number of granulocytes in the circulation.

A condition characterized by an abnormally large number of granulocytes in blood or tissues.

An excess of granulocytes in the blood.

• masked g. — an increase in the total number of granulocytes but not the leukocyte count, resulting from an increase in the marginal pool.
• paraneoplastic g. — seen in association with neoplasia; the cause is unknown.

Granulocytosis
Classification and external resources
DiseasesDB	8995

In medicine, granulocytosis is the presence in peripheral blood of an increased number of granulocytes, a category of white blood cells. Often, the word refers to an increased neutrophil granulocyte count, as neutrophils are the main granulocytes.

Causes

An increase in eosinophil granulocyte is known as eosinophilia.

Granulocytosis can be a feature of a number of diseases:

• Infection, especially bacterial
• Malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML)
• Autoimmune disease

Prognostic relations

In cardiovascular disease, increased white blood cell counts have been shown to indicate a worse prognosis.

See also

• Agranulocytosis
• Complete blood count
• Bandemia

v • d • e Pathology: hematology · myeloid hematologic disease (primarily D50-D77 · 280-289) Red blood cells ↑ Polycythemia · Macrocytosis ↓ Anemia Nutritional Micro-: Iron deficiency anemia (Plummer-Vinson syndrome) Macro-: Megaloblastic anemia (Pernicious anemia) Hemolytic (mostly Normo-; thalassemia) Hereditary enzymopathy: G6PD · glycolysis (PK, TI, HK) hemoglobinopathy: Thalassemia (alpha, beta, delta)  · Sickle-cell disease/trait · HPFH membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Ovalocytosis) · Hereditary stomatocytosis Acquired Autoimmune (WAHA, CAD, PCH) membrane (PNH) MAHA · TM (HUS) Drug-induced autoimmune hemolytic anemia · Drug-induced nonautoimmune hemolytic anemia Aplastic (mostly Normo-) Hereditary: Fanconi anemia · Diamond-Blackfan anemia Acquired: PRCA · Sideroblastic anemia · Myelophthisic Blood tests MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic) Other Methemoglobinemia · Sulfhemoglobinemia · Reticulocytopenia Coagulation/ coagulopathy/ bleeding diathesis ↑ Thrombocytosis Essential thrombocytosis Hypercoagulability primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid) ↓ Thrombocytopenia/ purpura Nonthrombocytopenic purpura: Henoch-Schönlein Thrombocytopenic purpura: ITP (Evans syndrome) · TM (TTP) Heparin-induced thrombocytopenia Platelet function adhesion (Bernard-Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky-Pudlak syndrome, Gray platelet syndrome) Clotting factor Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II · XIII Monocytes/ macrophages ↑ Histiocytosis · Chronic granulomatous disease -cytosis: Monocytosis ↓ -penia: Monocytopenia Granulocytes ↑ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia, Bandemia) ↓ -penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome · Eosinopenia · Basopenia) see also myeloid malignancy and immune disorders ↑ means increased, ↓ means decreased

This medical sign article is a stub. You can help Wikipedia by expanding it.

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)