Granzyme B is a protein that in humans is encoded by the GZMB gene.[1]
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis, bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[2]
See also
References
Further reading
- Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand journal of medicine 25 (6): 793–9. PMID 8770355.
- Cohen GM (1997). "Caspases: the executioners of apoptosis.". Biochem. J. 326 ( Pt 1): 1–16. PMID 9337844.
- Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions.". Curr. Opin. Immunol. 15 (5): 533–43. doi:10.1016/S0952-7915(03)00107-9. PMID 14499262.
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1fq3: CRYSTAL STRUCTURE OF HUMAN GRANZYME B
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1iau: HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO
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