Hurthle cell

(pathology) Enlarged epithelial cells of the thyroid follicles containing acidophilic cytoplasm, seen most frequently in adenomas.

A thyroid follicular cell that is enlarged and has acidophilic cytoplasm, especially present in adenomas.

Large oxyphilic, eosinophilic cells found in the thyroid gland. They are metabolically altered follicular cells which accumulate large numbers of mitochondria. See also Hürthle cell tumor (below).

• H. c. tumor — a new growth of the thyroid gland composed wholly or predominantly of large cells (Hürthle cells) having abundant granular, eosinophilic cytoplasm. Such tumors are usually benign (Hürthle cell adenoma) but on occasion may be locally invasive or may rarely metastasize (Hürthle cell carcinoma, or malignant Hürthle cell tumor). Called also oxyphilic adenoma of thyroid gland.

Hurthle cell
Classification and external resources
ICD-10	C73.9
ICD-O:	8290/0
DiseasesDB	31956
eMedicine	med/1045
MeSH	[1]

A Hürthle cell is a cell in the thyroid that is often associated with Hashimoto's thyroiditis^[1] as well as follicular thyroid cancer.

Contents 1 Histology 2 Clinical significance 3 Eponym 4 See also 5 References 6 External links

Histology

Hürthle cells are characterized as enlarged epithelial cells with abundant eosinophilic granular cytoplasm as a result of altered mitochondria.^[2] They generally stain pink and are prominently found in histological sections of thyroid glands affected with Hashimoto's.

Clinical significance

A Hürthle cell adenoma is a type of thyroid benign tumor^[3] that, in rare cases, has the potential to become malignant^[4] and metastasize (Hürthle cell carcinoma). Hürthle cells are also found in Hashimoto's thyroiditis and toxic and nontoxic nodular goiter. Hürthle cells are hypothesized to be of follicular epithelial origin.

Eponym

It is named for Karl Hürthle.^[5][6]

See also

• adenoma
• oncocytoma
• oxyphil cell

References

1. ^ "Endocrine Pathology". http://library.med.utah.edu/WebPath/ENDOHTML/ENDO018.html. Retrieved on 2009-05-07. 
2. ^ Aytug, Serhat (June 13, 2006). "Hurthle Cell Carcinoma". eMedicine. http://www.emedicine.com/med/topic1045.htm. 
3. ^ Hürthle cell tumor at Dorland's Medical Dictionary
4. ^ Qian L, Pucci R, Castro CY, Eltorky MA (October 2004). "Renal cell carcinoma metastatic to Hürthle cell adenoma of thyroid". Ann Diagn Pathol 8 (5): 305–8. PMID 15494939. http://linkinghub.elsevier.com/retrieve/pii/S1092913404000735. 
5. ^ synd/2742 at Who Named It?
6. ^ M. Askanazy. Pathologisch-anatomische Beiträge zur Kenntniss des morbus basedowii, insbesondere uber die dabei auftretende Muskelerkrankkung. Deutsches Archiv für klinische Medicin, Leipzig, 1898, 61:118-186.

External links

• The Doctor's Doctor at thedoctorsdoctor.com
• Illustration at thyroidmanager.org
• EndocrineWeb at endocrineweb.com
• HKU at hku.hk
• Image at upmc.edu

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v • d • e Tumors: endocrine gland neoplasia (C73-C75/D34-D35, 193-194/226-227) Pancreas/ islets of Langerhans neuroendocrine tumors/islet cell carcinoma: α:Glucagonoma · β:Insulinoma · δ:Somatostatinoma · Gastrinoma · VIPoma Pituitary Prolactinoma · ACTH-secreting pituitary adenoma · Growth hormone-secreting pituitary adenoma Craniopharyngioma Pituicytoma Thyroid carcinoma: epithelial cell (Papillary, Follicular/Hurthle cell) · parafollicular cell (Medullary) · Anaplastic Thyroid adenoma Parathyroid Parathyroid adenoma · Parathyroid carcinoma Adrenal tumor adrenal cortex (Adrenocortical adenoma, Adrenocortical carcinoma) adrenal medulla (Pheochromocytoma, Neuroblastoma) · see also Paraganglioma Gonads see genital neoplasia Pinealoma Pinealoblastoma · Pineocytoma Multiple endocrine neoplasia 1 · 2A · 2B see also disorders, congenital

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