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Hepatocyte growth factor (hepapoietin A; scatter factor)
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| PDB rendering based on 1bht. | ||||||||||||||
| Available structures: 1bht, 1gmn, 1gmo, 1gp9, 1nk1, 1shy, 1si5, 2hgf | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | HGF; F-TCF; HGFB; HPTA; SF | |||||||||||||
| External IDs | OMIM: 142409 MGI: 96079 HomoloGene: 503 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3082 | 15234 | ||||||||||||
| Ensembl | ENSG00000019991 | ENSMUSG00000028864 | ||||||||||||
| Uniprot | P14210 | O55027 | ||||||||||||
| Refseq | NM_000601 (mRNA) NP_000592 (protein) |
NM_010427 (mRNA) NP_034557 (protein) |
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| Location | Chr 7: 81.17 - 81.24 Mb | Chr 5: 16.07 - 16.13 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.[1]
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.[2]
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Interactions
Hepatocyte growth factor has been shown to interact with C-Met.[3][4]
References
- ^ Gallagher, J.T., Lyon, M. (2000). "Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens". in Iozzo, M, V.. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. pp. 27–59.
- ^ "Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3082.
- ^ Comoglio, P M (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS (SWITZERLAND) 65: 131-65. ISSN 1023-294X. PMID 8380735.
- ^ Naldini, L; Weidner K M, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan R P, Hartmann G, Zarnegar R, Michalopoulos G K (Oct. 1991). "Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor". EMBO J. (ENGLAND) 10 (10): 2867-78. ISSN 0261-4189. PMID 1655405.
Further reading
- Nakamura T (1992). "Structure and function of hepatocyte growth factor.". Prog. Growth Factor Res. 3 (1): 67–85. doi:. PMID 1838014.
- Ware LB, Matthay MA (2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (5): L924–40. doi:. PMID 11943656.
- Funakoshi H, Nakamura T (2003). "Hepatocyte growth factor: from diagnosis to clinical applications.". Clin. Chim. Acta 327 (1-2): 1–23. doi:. PMID 12482615.
- Skibinski G (2004). "The role of hepatocyte growth factor/c-met interactions in the immune system.". Arch. Immunol. Ther. Exp. (Warsz.) 51 (5): 277–82. PMID 14626426.
- Kalluri R, Neilson EG (2004). "Epithelial-mesenchymal transition and its implications for fibrosis.". J. Clin. Invest. 112 (12): 1776–84. doi:. PMID 14679171.
- Hurle RA, Davies G, Parr C, et al. (2006). "Hepatocyte growth factor/scatter factor and prostate cancer: a review.". Histol. Histopathol. 20 (4): 1339–49. PMID 16136515.
- Kemp LE, Mulloy B, Gherardi E (2006). "Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.". Biochem. Soc. Trans. 34 (Pt 3): 414–7. doi:. PMID 16709175.
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See also
- growth factor
- hepatocyte growth factor receptor (HGFR)
External links
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