Hess or Heß as a surname may refer to:
- Damian Hess aka MC Frontalot, nerdcore rapper
- Dean Hess (born 1917), American Air Force Colonel
- Erika Hess (born 1962), Swiss alpine skier
- Germain Henri Hess (1802–1850), Russian-Swiss chemist
- Harry Hess (1906–1969), American geologist best known for his theories on sea floor spreading
- Heinrich von Heß (1788–1870), Austrian fieldmarshall
- Heinrich Maria von Hess, German painter
- Jared Hess (born 1979), American writer and director of Napoleon Dynamite
- Johann Hess (Hesse), (1490–1547)
- Johann Jakob Hess, (1741–1828)
- Markus Hess, German hacker
- Moses Hess (1812–1875), Jewish philosopher and proto-Zionist
- Myra Hess (1890–1965), British pianist
- Orvan Hess (1906–2002), doctor who invented the fetal heart monitor
- Peter von Hess, German Painter
- Petra Heß, SPD Bundestag member
- Richard Hess (American painter) (born 1934)
- Rudolf Hess (Heß) (1894–1987), Deputy Führer of Nazi Germany
- Todd David Hess, (born 1960), USAF Colonel, first AF Member to receive Army Legion of Merit
- Victor Francis Hess (1883–1964), Austrian-American physicist who discovered cosmic rays
- Walter David Hess (1938–1991) South African Jewish Educator and Executive Vice President of UIA Canada
- Walter Rudolf Hess (1881–1973), Swiss physiologist who won the Nobel Prize in Physiology or Medicine in 1949
- Willy Hess (violinist) (1859–1939), German famous violin virtuoso
- Willy Hess (composer) (1906–1997), Swiss musicologist, composer, and famous Beethoven scholar
- Wolf Rüdiger Hess (Heß) (1937–2001), German architect, right extremist and son of Rudolf Hess
See also
- Rudolf Hoess (also Höss or Höß), commandant of Auschwitz concentration camp during World War II
- Helius Eobanus Hessus (1488–1540), German Latin poet
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